Why is congenital Zika syndrome asymmetrically distributed among human populations?

被引:32
作者
Barbeito-Andres, Jimena [1 ,2 ]
Schuler-Faccini, Lavinia [3 ,4 ]
Garcez, Patricia Pestana [1 ]
机构
[1] Univ Fed Rio de Janeiro, Inst Biomed Sci, Rio De Janeiro, Brazil
[2] Consejo Nacl Invest Cient & Tecn, ENyS, Inst Studies Neurosci & Complex Syst Studies, Buenos Aires, DF, Argentina
[3] Univ Fed Rio Grande do Sul, Dept Genet, Inst Biosci, Porto Alegre, RS, Brazil
[4] Hosp Clin Porto Alegre, Med Genet Serv, Inst Nacl Genet Med Populac, Porto Alegre, RS, Brazil
关键词
VIRUS; ENHANCEMENT; INFECTION; TRANSMISSION; SPECTRUM; DISEASE; GROWTH; RIGHTS;
D O I
10.1371/journal.pbio.2006592
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus' genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
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页数:11
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