Serum Levels of High-sensitivity C-Reactive Protein at Admission Are More Strongly Associated with Poststroke Depression in Acute Ischemic Stroke than Homocysteine Levels

被引:51
作者
Tang, Chao-Zhi [1 ]
Zhang, Yu-Ling [1 ]
Wang, Wen-Sheng [1 ]
Li, Wei-Guo [1 ]
Shi, Ji-Peng [2 ]
机构
[1] Henan Normal Univ, Coll Life Sci, Mol Med Lab, 46 Jianshedong Rd, Xinxiang 453007, Henan Province, Peoples R China
[2] Xinxiang Med Univ, Affiliated Hosp 1, Xinxiang, Henan Province, Peoples R China
基金
中国国家自然科学基金;
关键词
High-sensitivity C-reactive protein; Homocysteine; Inflammation; Stroke; Depression; CEREBRAL INFARCTION; IMMUNE ACTIVATION; DISEASE; SYMPTOMS; BRAIN; LIPOPOLYSACCHARIDE; HOMOCYST(E)INE; MATTER; FOLATE;
D O I
10.1007/s12035-015-9186-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Inflammatory processes have fundamental roles in depression. The primary purpose of this study was to assess the serum levels of high-sensitivity C-reactive protein (Hs-CRP) and homocysteine (HCY) at admission to the presence of poststroke depression (PSD). From December 2012 to December 2013, first-ever acute ischemic stroke patients who were admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Serum levels of Hs-CRP and HCY were tested at admission. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6 months after stroke. Ninety-five patients (42.0 %) showed depression (major + minor) at 6 months after admission, and in 69 patients (30.5 %), this depression was classified as major. In the 69 patients with major depression, our results showed significantly higher Hs-CRP and HCY levels at admission than patients without major depression. After adjusting all other possible covariates, Hs-CRP and HCY still were independent predicators of PSD with adjusted OR of 1.332 (95 % CI, 1.230-1.452; P < 0.001) and 1.138 (95 % CI, 1.072-1.274; P < 0.001), respectively. The area under the receiver operating characteristic curve values of Hs-CRP and HCY were 0.765 (95 % CI, 0.701-0.9825) and 0.684 (95 % CI, 0.610-0.757) for PSD, respectively. The prognostic accuracy of combined model (HCY and Hs-CRP) was higher compared to those biomarkers alone and other markers. Elevated serum levels of Hs-CRP and HCY at admission were found to be associated with depression 6 months after stroke, suggesting that these alterations might participate in the pathophysiology of depression symptoms in stroke patients.
引用
收藏
页码:2152 / 2160
页数:9
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