DNA Repair Has a New FAN1 Club

被引：11

作者：

O'Donnell, Lara ^{[1
]}

Durocher, Daniel ^{[1
,2
]}

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

来源：

MOLECULAR CELL | 2010年 / 39卷 / 02期

关键词：

CROSS-LINK REPAIR; MONOUBIQUITINATED FANCD2; NUCLEASE; IDENTIFICATION; KIAA1018/FAN1; PATHWAY;

D O I：

10.1016/j.molcel.2010.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent issues of Molecular Cell, Cell, and Science, Smogorzewska et al. (2010), MacKay et al. (2010), Kratz et al. (2010), and Liu et al. (2010) identify FAN1 as a nuclease that is recruited to sites of interstrand crosslinks by ubiquitylated FANCD2, where it participates in DNA repair. The identification of FAN1 fills a missing link in interstrand crosslink DNA repair.

引用

页码：167 / 169

页数：3

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