Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies

被引：57

作者：

Lu, Lei ^{[1
,2
]}

Chen, Gaoxian ^{[1
,2
]}

Qiu, Yuanyuan ^{[1
,2
]}

Li, Mingwang ^{[1
,2
]}

Liu, Dianhua ^{[1
]}

Hu, Dehui ^{[1
]}

Gu, Xiajing ^{[1
]}

Xiao, Zeyu ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Dept Pharmacol, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Translat Med Collaborat Innovat Ctr, Shanghai 200025, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Collaborat Innovat Ctr Syst Biomed, Shanghai 200025, Peoples R China

来源：

SCIENCE BULLETIN | 2016年 / 61卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Colon targeting; Nanoparticles; Oral drug delivery; Inflammatory bowel disease; INFLAMMATORY-BOWEL-DISEASE; LOADED PLGA NANOPARTICLES; EXPERIMENTAL COLITIS; PEYERS-PATCHES; POLYMERIC NANOPARTICLES; GASTROINTESTINAL-TRACT; CONTROLLED-RELEASE; MUCOSA; THERAPY; MUCUS;

D O I：

10.1007/s11434-016-1056-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Colon-targeted oral delivery is crucial for the treatment of colon-related diseases, as this delivery strategy enables precise drug administration to the diseased site, enhances drug bioavailability, and improves patient compliance. In particular, nanoparticle-based oral formulations shield drugs from the harsh gastrointestinal environment, and selectively increase drug concentration inside diseased colon cells, thus elevating therapeutic efficacy while reducing systemic toxicity. In this review, we elaborate recent progress in this area, with emphasis on the pathophysiological characteristics of colon site and design strategies to take advantage of these characteristics for colon targeting.

引用

页码：670 / 681

页数：12

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