Room-temperature Stille cross-couplings of alkenyltin reagents and functionalized alkyl bromides that possess β hydrogens

被引：102

作者：

Menzel, K ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 13期

关键词：

D O I：

10.1021/ja0344563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This communication describes a significant expansion in the scope of Stille reactions of Csp3 -X electrophiles, specifically, that Pd/P(t-Bu)2Me catalyzes the room-temperature cross-coupling of a variety of functionalized, β-hydrogen-containing alkyl bromides with an array of alkenyltin reagents. The structure of the phosphine (P(t-Bu)2Me) is well suited for facilitating oxidative addition and avoiding β-hydride elimination, while the fluoride serves to activate the tin reagent for efficient transmetalation. Copyright © 2003 American Chemical Society.

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页码：3718 / 3719

页数：2

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