Maternal inheritance of bifidobacterial communities and bifidophages in infants through vertical transmission

被引：254

作者：

Duranti, Sabrina ^{[1
]}

Lugli, Gabriele Andrea ^{[1
]}

Mancabelli, Leonardo ^{[1
]}

Armanini, Federica ^{[2
]}

Turroni, Francesca ^{[1
]}

James, Kieran ^{[3
,4
]}

Ferretti, Pamela ^{[2
]}

Gorfer, Valentina ^{[5
]}

Ferrario, Chiara ^{[1
]}

Milani, Christian ^{[1
]}

Mangifesta, Marta ^{[6
]}

Anzalone, Rosaria ^{[1
]}

Zolfo, Moreno ^{[2
]}

Viappiani, Alice ^{[6
]}

Pasolli, Edoardo ^{[2
]}

Bariletti, Ilaria ^{[5
]}

Canto, Rosarita ^{[5
]}

Clementi, Rosanna ^{[5
]}

Cologna, Marina ^{[5
]}

Crifo, Tiziana ^{[5
]}

Cusumano, Giuseppina ^{[5
]}

Fedi, Sabina ^{[5
]}

Gottardi, Stefania ^{[5
]}

Innamorati, Claudia ^{[5
]}

Mase, Caterina ^{[5
]}

Postai, Daniela ^{[5
]}

Savoi, Daniela ^{[5
]}

Soffiati, Massimo ^{[5
]}

Tateo, Saverio ^{[5
]}

Pedrotti, Anna ^{[5
]}

Segata, Nicola ^{[2
]}

van Sinderen, Douwe ^{[3
,4
]}

Ventura, Marco ^{[1
]}

机构：

[1] Univ Parma, Lab Probiogen, Dept Chem Life Sci & Environm Sustainabil, Parco Area Sci 11a, I-43124 Parma, Italy

[2] Univ Trento, Ctr Integrat Biol, Trento, Italy

[3] Natl Univ Ireland, APC Microbiome Inst, Cork, Ireland

[4] Natl Univ Ireland, Sch Microbiol, Biosci Inst, Cork, Ireland

[5] Azienda Prov Serv Sanit, Trento, Italy

[6] GenProbio Srl, Parma, Italy

来源：

MICROBIOME | 2017年 / 5卷

基金：

爱尔兰科学基金会;

关键词：

Microbiota; Virome; Microbiome; Bifidobacteria; Vertical transmission; HUMAN GUT VIROME; HUMAN-MILK OLIGOSACCHARIDES; BIFIDUM PRL2010; BACTERIAL MICROBIOME; GENOME ANALYSIS; BREVE UCC2003; EARLY-LIFE; MOTHER; DIVERSITY; STRAINS;

D O I：

10.1186/s40168-017-0282-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother's fecal/vaginal microbiota and human milk. Results: The composition of bifidobacterial communities of 25 mother-infant pairs was investigated based on an internal transcribed spacer (ITS) approach, combined with cultivation-mediated and genomic analyses. We identified bifidobacterial strains/communities that are shared between mothers and their corresponding newborns. Notably, genomic analyses together with growth profiling assays revealed that bifidobacterial strains that had been isolated from human milk are genetically adapted to utilize human milk glycans. In addition, we identified particular bacteriophages specific of bifidobacterial species that are common in the viromes of mother and corresponding child. Conclusions: This study highlights the transmission of bifidobacterial communities from the mother to her child and implies human milk as a potential vehicle to facilitate this acquisition. Furthermore, these data represent the first example of maternal inheritance of bifidobacterial phages, also known as bifidophages in infants following a vertical transmission route.

引用

页数：13

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