Hemolytic polar steroidal constituents of the starfish Aphelasterias japonica

被引：44

作者：

Ivanchina, NV

Kicha, AA

Kalinovsky, AI

Dmitrenok, PS

Stonik, VA ^{[1
]}

Riguera, R

Jiménez, C

机构：

[1] Russian Acad Sci, Far E Branch, Pacific Inst Bioorgan Chem, Vladivostok 22, Russia

[2] Univ Santiago de Compostela, Dept Quim Organ, Santiago De Compostela 15706, Spain

[3] Univ Santiago de Compostela, Inst Acuicultura, Santiago De Compostela 15706, Spain

[4] Univ A Coruna, Fac Ciencias, Dept Quim Fundamental & Ind, La Coruna 15071, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 08期

关键词：

D O I：

10.1021/np000030f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A reinvestigation of the polar steroid fraction from the starfish Aphelasterias japonica, collected near the Russian shore of the Sea of Japan, has afforded two new compounds, the disulfated quinovoside aphelasteroside C (1) and the monosulfated polyhydroxysteroid aphelaketotriol (2). Compounds 1 and 2 contain a unique 23-oxo-24-hydroxylated side chain that is unprecedented in marine steroids. The known compounds cheliferoside L1 (3), 3-O-sulfoasterone (4), forbeside E3 (5), and 3-O-sulfothornasterol A (6) were also isolated from this source. Compounds 1-3, 5, and 6 showed hemolytic activity to mouse erythrocytes.

引用

页码：1178 / 1181

页数：4

共 11 条

[1] STARFISH SAPONINS .47. STEROIDAL GLYCOSIDE SULFATES AND POLYHYDROXYSTEROIDS FROM APHELASTERIAS-JAPONICA [J].

FINAMORE, E ;

ZOLLO, F ;

MINALE, L ;

YASUMOTO, T .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (06) :767-772

[2] NOVEL SULFATED STEROL GLYCOSIDES FROM ASTERIAS-FORBESI [J].

FINDLAY, JA ;

HE, ZQ .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (03) :710-712

[3] Stimulatory effects of starfish sapogenins (Asterias amurensis and Lethasterias nanimensis chelifera) on molluscan heart (Spisula sachalinensis) [J].

Gorshkov, BA ;

Kapustina, II ;

Kicha, AA ;

Aminin, DL ;

Gorshkova, IA .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1998, 120 (02) :235-239

[4] STUDIES ON ASTEROSAPONINS .5. NOVEL STEROID CONJUGATE, 5 ALPHA-PREGN-9(11)-ENE-3 BETA,6 ALPHA-DIOL-20-ONE-3-SULFATE, FROM A STARFISH SAPONIN, ASTEROSAPONIN-A [J].

IKEGAMI, S ;

KAMIYA, Y ;

TAMURA, S .

TETRAHEDRON, 1973, 29 (13) :1807-1810

[5] New steroid glycosides from the deep-water starfish Mediaster murrayi [J].

Kicha, AA ;

Kalinovsky, AI ;

Ivanchina, NV ;

Stonik, VA .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (02) :279-282

[6]

Kicha AA, 1992, KHIM PRIR SOEDIN, V1, P145

[7]

KICHA AA, 1997, IZV AKAD NAUK K, P190

[8]

KICHA AA, 1993, KHIM PRIR SOEDIN, V9, P249

[9]

KICHA AA, 1991, KHIM PRIR SOEDIN, V4, P520

[10]

KOBAYASHI M, 1983, CHEM PHARM BULL, V31, P1848

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