Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers

被引：113

作者：

Samori, Cristian ^{[3
]}

Ali-Boucetta, Hanene ^{[2
]}

Sainz, Raquel ^{[3
]}

Guo, Chang ^{[2
]}

Toma, Francesca Maria ^{[1
,4
]}

Fabbro, Chiara ^{[1
]}

da Ros, Tatiana ^{[1
]}

Prato, Maurizio ^{[1
]}

Kostarelos, Kostas ^{[2
]}

Bianco, Alberto ^{[3
]}

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Univ London, Sch Pharm, Ctr Drug Delivery, Nanomed Lab, London WC1N 1AX, England

[3] CNRS, Inst Biol Mol & Cellulaire, Lab Immunol & Chim Therapeut, F-67000 Strasbourg, France

[4] SISSA, I-34014 Trieste, Italy

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 09期

关键词：

DRUG-DELIVERY; IN-VIVO; CATHEPSIN-B; CELLS; FUNCTIONALIZATION; STABILITY; DESIGN; FOLATE; VITRO;

D O I：

10.1039/b923560d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.

引用

页码：1494 / 1496

页数：3

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