Cellular mechanisms underlying obesity-induced arterial stiffness

被引:128
作者
Aroor, Annayya R. [1 ,4 ]
Jia, Guanghong [1 ,4 ]
Sowers, James R. [1 ,2 ,3 ,4 ,5 ]
机构
[1] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO USA
[2] Univ Missouri, Dept Med Pharmacol, Sch Med, Columbia, MO USA
[3] Univ Missouri, Sch Med, Dept Physiol, Columbia, MO 65212 USA
[4] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA
[5] Dalton Cardiovasc Ctr Columbia, Columbia, MO USA
关键词
cardiorenal metabolic syndrome; cardiovascular disease; cardiovascular stiffness; Western diet; PERIVASCULAR ADIPOSE-TISSUE; NITRIC-OXIDE SYNTHASE; GLYCATION END-PRODUCTS; VASCULAR INSULIN-RESISTANCE; AORTIC STIFFNESS; MINERALOCORTICOID RECEPTOR; WESTERN DIET; ENDOTHELIAL DYSFUNCTION; DIASTOLIC DYSFUNCTION; MOLECULAR-MECHANISMS;
D O I
10.1152/ajpregu.00235.2016
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults. There is mounting evidence that arterial stiffness in obesity is an independent and strong predictor of cardiovascular disease (CVD), cognitive functional decline, and chronic kidney disease. Cardiovascular stiffness is a precursor to atherosclerosis, systolic hypertension, cardiac diastolic dysfunction, and impairment of coronary and cerebral flow. Moreover, premenopausal women lose the CVD protection normally afforded to them in the setting of obesity, insulin resistance, and diabetes, and this loss of CVD protection is inextricably linked to an increased propensity for arterial stiffness. Stiffness of endothelial and vascular smooth muscle cells, extracellular matrix remodeling, perivascular adipose tissue inflammation, and immune cell dysfunction contribute to the development of arterial stiffness in obesity. Enhanced endothelial cortical stiffness decreases endothelial generation of nitric oxide, and increased oxidative stress promotes destruction of nitric oxide. Our research over the past 5 years has underscored an important role of increased aldosterone and vascular mineralocorticoid receptor activation in driving development of cardiovascular stiffness, especially in females consuming a Western diet. In this review the cellular mechanisms of obesity-associated arterial stiffness are highlighted.
引用
收藏
页码:R387 / R398
页数:12
相关论文
共 149 条
[1]   Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome [J].
Abraham, Nader G. ;
Junge, Joshua M. ;
Drummond, George S. .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2016, 37 (01) :17-36
[2]   Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue [J].
Antonopoulos, Alexios S. ;
Margaritis, Marios ;
Coutinho, Patricia ;
Shirodaria, Cheerag ;
Psarros, Costas ;
Herdman, Laura ;
Sanna, Fabio ;
De Silva, Ravi ;
Petrou, Mario ;
Sayeed, Rana ;
Krasopoulos, George ;
Lee, Regent ;
Digby, Janet ;
Reilly, Svetlana ;
Bakogiannis, Constantinos ;
Tousoulis, Dimitris ;
Kessler, Benedikt ;
Casadei, Barbara ;
Channon, Keith M. ;
Antoniades, Charalambos .
DIABETES, 2015, 64 (06) :2207-2219
[3]   DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and Associated Cardiovascular and Renal Insulin Resistance in Obesity and Diabetes [J].
Aroor, Annayya ;
McKarns, Susan ;
Nistala, Ravi ;
DeMarco, Vincent ;
Gardner, Michael ;
Garcia-Touza, Mariana ;
Whaley-Connell, Adam ;
Sowers, James R. .
CARDIORENAL MEDICINE, 2013, 3 (01) :48-56
[4]   Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice [J].
Aroor, Annayya R. ;
Jia, Guanghong ;
Habibi, Javad ;
Sun, Zhe ;
Ramirez-Perez, Francisco I. ;
Brady, Barron ;
Chen, Dongqing ;
Martinez-Lemus, Luis A. ;
Manrique, Camila ;
Nistala, Ravi ;
Whaley-Connell, Adam T. ;
Demarco, Vincent G. ;
Meininger, Gerald A. ;
Sowers, James R. .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2017, 74 :32-40
[5]   Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system [J].
Aroor, Annayya R. ;
Sowers, James R. ;
Jia, Guanghong ;
DeMarco, Vincent G. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2014, 307 (04) :H477-H492
[6]  
Aroor Annayya R, 2013, Front Endocrinol (Lausanne), V4, P161, DOI 10.3389/fendo.2013.00161
[7]   Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance [J].
Aroor, Annayya R. ;
McKarns, Susan ;
DeMarco, Vincent G. ;
Jia, Guanghong ;
Sowers, James R. .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2013, 62 (11) :1543-1552
[8]   Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome [J].
Aroor, Annayya R. ;
Mandavia, Chirag ;
Ren, Jun ;
Sowers, James R. ;
Pulakat, Lakshmi .
CARDIORENAL MEDICINE, 2012, 2 (02) :87-109
[9]   Insulin Resistance and Heart Failure: Molecular Mechanisms [J].
Aroor, Annayya R. ;
Mandavia, Chirag H. ;
Sowers, James R. .
HEART FAILURE CLINICS, 2012, 8 (04) :609-+
[10]   Long-term use of low-dose spironolactone in spontaneously hypertensive rats: Effects on left ventricular hypertrophy and stiffness [J].
Baldo, Marcelo P. ;
Forechi, Ludimila ;
Morra, Elis A. S. ;
Zaniqueli, Divanei ;
Machado, Rebeca C. ;
Lunz, Wellington ;
Rodrigues, Sergio L. ;
Mill, Jose Geraldo .
PHARMACOLOGICAL REPORTS, 2011, 63 (04) :975-982