Mid-infrared (IR) lasers are currently an area of rapid development, with several competing technologies. In traditional gas lasers, the effective interaction length is limited and the system as a whole is bulky and inflexible, limiting their applications. Standard gain fibers cannot be used in the mid-IR because the glass forming the fiber core is not transparent at these longer wavelengths. In this Letter, we report the demonstration of a mid-IR fiber gas laser using feedback in an optical cavity. The laser uses acetylene gas in a high-performance silica hollow-core fiber as the gain medium, and lases either continuous wave or synchronously pumped when pumped by telecom-wavelength diode lasers. We have demonstrated lasing on a number of transitions in the spectral band of 3.1-3.2 mu m. The system could be extended to other selected molecular species to generate output in the spectral band up to 5 mu m, and it has excellent potential for power scaling. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License.