Brain-immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders

被引：0

作者：

Zhao, Fangyi ^{[1
]}

Li, Bingjin ^{[1
]}

Yang, Wei ^{[1
]}

Ge, Tongtong ^{[1
]}

Cui, Ranji ^{[1
]}

机构：

[1] Second Hosp Jilin Univ, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China

来源：

CELL PROLIFERATION | 2022年 / 55卷 / 10期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

MAJOR DEPRESSIVE DISORDER; EARLY-LIFE STRESS; CENTRAL-NERVOUS-SYSTEM; MICROGLIAL ACTIVATION; PREFRONTAL CORTEX; NITRIC-OXIDE; PARKINSONS-DISEASE; INFLAMMATORY MARKERS; CYTOKINE ALTERATIONS; ASTROCYTE PATHOLOGY;

D O I：

10.1111/cpr.13295

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objectives Cognitive dysfunction has been identified as a major symptom of a series of psychiatric disorders. Multidisciplinary studies have shown that cognitive dysfunction is monitored by a two-way interaction between the neural and immune systems. However, the specific mechanisms of cognitive dysfunction in immune response and brain immune remain unclear. Materials and methods In this review, we summarized the relevant research to uncover our comprehension of the brain-immune interaction mechanisms underlying cognitive decline. Results The pathophysiological mechanisms of brain-immune interactions in psychiatric-based cognitive dysfunction involve several specific immune molecules and their associated signaling pathways, impairments in neural and synaptic plasticity, and the potential neuro-immunological mechanism of stress. Conclusions Therefore, this review may provide a better theoretical basis for integrative therapeutic considerations for psychiatric disorders associated with cognitive dysfunction.

引用

页数：25

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