Pesticides, Gene Polymorphisms, and Bladder Cancer Among Egyptian Agricultural Workers

被引：35

作者：

Amr, Sania ^{[1
]}

Dawson, Rebecca ^{[1
]}

Saleh, Doa'a A. ^{[2
]}

Magder, Laurence S. ^{[1
]}

St George, Diane Marie ^{[1
]}

El-Daly, Mai ^{[3
]}

Squibb, Katherine ^{[4
]}

Mikhail, Nabiel N. ^{[5
]}

Abdel-Hamid, Mohamed ^{[6
]}

Khaled, Hussein ^{[7
]}

Loffredo, Christopher A. ^{[8
]}

机构：

[1] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA

[2] Cairo Univ, Dept Community Med, Cairo, Egypt

[3] Menoufia Univ, Natl Liver Inst, Al Minufya, Egypt

[4] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[5] Assiut Univ, South Egypt Canc Inst, Dept Biostat & Canc Epidemiol, Assiut, Egypt

[6] Menia Univ, Dept Microbiol & Immunol, Al Minya, Egypt

[7] Cairo Univ, Natl Canc Inst, Dept Chemotherapy, Cairo, Egypt

[8] Georgetown Univ, Med Ctr, Lombardi Canc Ctr, Washington, DC 20007 USA

来源：

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2015年 / 70卷 / 01期

基金：

美国国家卫生研究院;

关键词：

bladder cancer; agricultural workers; epidemiology; pesticides; Egypt; gene polymorphism; MANGANESE SUPEROXIDE-DISMUTASE; NAD(P)H-QUINONE-OXIDOREDUCTASE-1 NQO1; NAD(P)H-QUINONE OXIDOREDUCTASE-1; ENVIRONMENTAL EXPOSURES; QUINONE OXIDOREDUCTASE; HYDROGEN-PEROXIDE; DT-DIAPHORASE; RISK-FACTORS; LUNG-CANCER; DNA-ADDUCTS;

D O I：

10.1080/19338244.2013.853646

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study examined the associations between pesticide exposure, genetic polymorphisms for NAD(P)H:quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confidence interval): 1.68 (1.23-2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25-2.56)) than for squamous cell (1.55 (1.03-2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19-3.85)) activities as compared with those with high NQO1 and low SOD2 genotypes (1.53 (0.73-3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.

引用

页码：19 / 26

页数：8

共 52 条

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[52] Urinary Bladder Cancer Risk Factors in Egypt: A Multicenter Case-Control Study [J].

Zheng, Yun-Ling ;

Amr, Sania ;

Saleh, Doa'a A. ;

Dash, Chiranjeev ;

Ezzat, Sameera ;

Mikhail, Nabiel N. ;

Gouda, Iman ;

Loay, Iman ;

Hifnawy, Tamer ;

Abdel-Hamid, Mohamed ;

Khaled, Hussein ;

Wolpert, Beverly ;

Abdel-Aziz, Mohamed A. ;

Loffredo, Christopher A. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2012, 21 (03) :537-546

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