Mitochondria: from cell death executioners to regulators of cell differentiation

被引：335

作者：

Kasahara, Atsuko ^{[1
]}

Scorrano, Luca ^{[2
,3
]}

机构：

[1] Univ Geneva, Dept Pathol & Immunol, CH-1211 Geneva, Switzerland

[2] Univ Padua, Dept Biol, I-35121 Padua, Italy

[3] Venetian Inst Mol Med, Dulbecco Telethon Inst, I-35129 Padua, Italy

来源：

TRENDS IN CELL BIOLOGY | 2014年 / 24卷 / 12期

关键词：

mitochondrial dynamics; differentiation; cardiomyocyte; heart; hair follicle; DRP1; MFN; OPA1; Notch signaling; Ca2+; NOTCH SIGNALING PATHWAY; NF-KAPPA-B; MAMMALIAN-CELLS; ENDOPLASMIC-RETICULUM; MITOFUSIN; ATP SYNTHASE; MEMBRANE ORGANIZATION; PROTEOLYTIC CLEAVAGE; MEDIATED APOPTOSIS; PROGENITOR CELLS;

D O I：

10.1016/j.tcb.2014.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most, if not all mitochondrial functions, including adenosine-5'-triphosphate (ATP) production and regulation of apoptosis and Ca2+ homeostasis, are inextricably linked to mitochondrial morphology and dynamics, a process controlled by a family of GTP-dependent dynamin related 'mitochondria-shaping' proteins. Mitochondrial fusion and fission directly influence mitochondrial metabolism, apoptotic and necrotic cell death, autophagy, muscular atrophy and cell migration. In this review, we discuss the recent evidence indicating that mitochondrial dynamics influence complex signaling pathways, affect gene expression and define cell differentiation. These findings extend the importance of mitochondria to developmental biology, far beyond their mere bioenergetic role.

引用

页码：761 / 770

页数：10

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