A decade of discovery in cancer genomics

被引：14

作者：

Offit, Kenneth ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Canc Biol & Genet, Dept Med,Clin Genet Serv, New York, NY 10021 USA

[2] Cornell Univ, Weill Cornell Med Coll, Dept Med & Publ Hlth, New York, NY 10021 USA

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2014年 / 11卷 / 11期

关键词：

SUSCEPTIBILITY; ASSOCIATION; MUTATIONS;

D O I：

10.1038/nrclinonc.2014.170

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the past decade, genetic testing for rare inherited mutations, such as BRCA1 and BRCA2 mutations, has been successfully incorporated into clinical practice. Next-generation sequencing of cancer-susceptibility genes and entire tumour genomes has transformed cancer care and prevention. The discoveries of new cancer syndromes have raised exciting opportunities and potential liabilities for cancer-dare providers seeking to incorporate genomic approaches into preventive oncology practice.

引用

页码：632 / 634

页数：3

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