Addressing the gut microbiome and implications for obesity

被引：6
作者：
Backhed, Fredrik [1 ,2 ]
机构：
[1] Univ Gothenburg, Sahlgrenska Ctr Cardiovasc & Metab Res, Wallenberg Lab, S-41345 Gothenburg, Sweden
[2] Univ Gothenburg, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden
来源：
INTERNATIONAL DAIRY JOURNAL | 2010年 / 20卷 / 04期
基金：
瑞典研究理事会;
关键词：
DIET-INDUCED OBESITY; INSULIN-RESISTANCE; WEIGHT-LOSS; ADIPOSE-TISSUE; LINOLEIC-ACID; MICE; ENDOTOXEMIA; INFLAMMATION; MICROFLORA; ADOLESCENTS;
D O I：
10.1016/j.idairyj.2009.11.012
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Identification of the gut microbiota as an environmental factor that modulates obesity and metabolic diseases has provided the medical and functional food industry with new targets to treat metabolic diseases. However, only limited knowledge about the mechanisms by which the gut microbiota contributes to these lifestyle diseases are known. The gut microbiota is involved in energy harvest from the diet, modulation of endocrine signalling, and promoting metabolic inflammation. This review will discuss how the gut microbiota is altered in obesity, some of the mechanisms by which it promotes disease development, and how pre- and probiotics may be used to improve metabolic diseases. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：259 / 261
页数：3
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