Electrospinning of nanofiber fibrinogen structures

被引：441
作者：
Wnek, GE
Carr, ME
Simpson, DG
Bowlin, GL
机构：
[1] Virginia Commonwealth Univ, Dept Biomed Engn, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Dept Chem Engn, Richmond, VA 23298 USA
[3] Virginia Commonwealth Univ, Dept Internal Med Hematol & Oncol, Richmond, VA 23298 USA
[4] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA 23298 USA
来源：
NANO LETTERS | 2003年 / 3卷 / 02期
关键词：
D O I：
10.1021/nl025866c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first results of electrospinning fibrinogen nanofibers for use as a tissue-engineering scaffold, wound dressing, or hemostatic bandage are reported. Structures composed of fibrinogen fibers with an average diameter of 80-700 nm were electrospun from solutions composed of human or bovine fibrinogen fraction I dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol and minimal essential medium (Earle's salts). In summary, the electrospinning process is a simple and efficient technique for the fabrication of 3D structures composed of fibrinogen fibers, as would be present in the physiologic environment.
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收藏
页码：213 / 216
页数：4
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