Synthesis of 5-methoxylated 3-pyrrolin-2-ones via the rearrangement of chlorinated pyrrolidin-2-ones

被引:35
作者
Ghelfi, F
Stevens, CV
Laureyn, I
Van Meenen, E
Rogge, TM
De Buyck, L
Nikitin, KV
Grandi, R
Libertini, E
Pagnoni, UM
Schenetti, L
机构
[1] Univ Ghent, Fac Agr & Appl Biol Sci, Dept Organ Chem, B-9000 Ghent, Belgium
[2] Univ Modena & Reggio Emilia, Dipartimento Chim, I-41100 Modena, Italy
[3] Natl Univ Ireland Univ Coll Dublin, Dept Chem, Dublin 4, Ireland
关键词
pyrrolidinones; pyrrolinones; lactams; eliminations;
D O I
10.1016/S0040-4020(03)00044-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The reaction of N-substituted 4-methyl-2-pyrrolidinones or 4-diethoxyphosphoryl analogues, carrying at least two chlorine atoms between the C(3) and C(6) carbons, with alkaline methoxide in methanol afforded the corresponding 5-methoxylated 3-pyrrolin-2-ones, useful adducts for the preparation of agrochemicals or medicinal compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1147 / 1157
页数:11
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