Experimental demonstration of charge inversion in a protein channel in the presence of monovalent cations
被引:8
作者:
Lidon Lopez, M.
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机构:
Univ Jaume 1, Dept Phys, Lab Mol Biophys, Castellon de La Plana 12080, SpainUniv Jaume 1, Dept Phys, Lab Mol Biophys, Castellon de La Plana 12080, Spain
Lidon Lopez, M.
[1
]
Queralt-Martin, Maria
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机构:
Univ Jaume 1, Dept Phys, Lab Mol Biophys, Castellon de La Plana 12080, SpainUniv Jaume 1, Dept Phys, Lab Mol Biophys, Castellon de La Plana 12080, Spain
Queralt-Martin, Maria
[1
]
Alcaraz, Antonio
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机构:
Univ Jaume 1, Dept Phys, Lab Mol Biophys, Castellon de La Plana 12080, SpainUniv Jaume 1, Dept Phys, Lab Mol Biophys, Castellon de La Plana 12080, Spain
Alcaraz, Antonio
[1
]
机构:
[1] Univ Jaume 1, Dept Phys, Lab Mol Biophys, Castellon de La Plana 12080, Spain
Bioelectrochemistry;
Electrophysiology;
Electrostatics;
Membrane protein;
Ion channel;
MEMBRANE;
BINDING;
PHYSICS;
D O I:
10.1016/j.elecom.2014.08.006
中图分类号:
O646 [电化学、电解、磁化学];
学科分类号:
081704 ;
摘要:
Charge inversion takes place when interfacial charges attract counterions in excess of their own nominal charge. To date, this phenomenon has been reported in a variety of membrane channel systems in the presence of multivalent cations. Here, we investigate the charge inversion phenomenon in a protein channel in solutions of monovalent cations. To this end, we perform selectivity experiments in salts of different cations, changing both the electrolyte concentration and the solution acidity. We show that charge inversion can be produced by two different mechanisms, namely specific adsorption and competitive binding. (C) 2014 Elsevier B.V. All rights reserved.