Hypoxia as a Modulator of Inflammation and Immune Response in Cancer

被引：30

作者：

Castillo-Rodriguez, Rosa A. ^{[1
,2
]}

Trejo-Solis, Cristina ^{[3
]}

Cabrera-Cano, Alfredo ^{[1
,4
]}

Gomez-Manzo, Saul ^{[5
]}

Davila-Borja, Victor Manuel

机构：

[1] Inst Nacl Pediatria, Lab Oncol Expt, Mexico City 04530, DF, Mexico

[2] Consejo Nacl Ciencia Tecnol CONACYT, Programa Invest Invest por Mexico, Mexico City 03940, DF, Mexico

[3] Inst Nacl Neurol Neurocirugia, Lab Expt Enfermedades Neurodegenerat, Mexico City 14269, DF, Mexico

[4] Univ Autonoma Metropolitana Iztapalapa, Div Ciencias Biol Salud, Posgrado Biol Expt, Mexico City 09340, DF, Mexico

[5] Inst Nacl Pediatria, Lab Bioquim Genet, Mexico City 04530, DF, Mexico

来源：

CANCERS | 2022年 / 14卷 / 09期

关键词：

hypoxia; inflammation; cancer; tumoral microenvironment; HIF-1; alpha; NF-kappa B; STAT; NF-KAPPA-B; INDUCIBLE FACTOR-I; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-ASSOCIATED MACROPHAGES; RENAL-CELL CARCINOMA; ANTI-VEGF THERAPY; CD8(+) T-CELLS; TRANSCRIPTION FACTOR; SUPPRESSOR-CELLS; PROSTATE-CANCER;

D O I：

10.3390/cancers14092291

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A clear association between hypoxia and cancer has heretofore been established; however, it has not been completely developed. In this sense, the understanding of the tumoral microenvironment is critical to dissect the complexity of cancer, including the reduction in oxygen distribution inside the tumoral mass, defined as tumoral hypoxia. Moreover, hypoxia not only influences the tumoral cells but also the surrounding cells, including those related to the inflammatory processes. In this review, we analyze the participation of HIF, NF-kappa B, and STAT signaling pathways as the main components that interconnect hypoxia and immune response and how they modulate tumoral growth. In addition, we closely examine the participation of the immune cells and how they are affected by hypoxia, the effects of the progression of cancer, and some innovative applications that take advantage of this knowledge, to suggest potential therapies. Therefore, we contribute to the understanding of the complexity of cancer to propose innovative therapeutic strategies in the future.

引用

页数：40

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