B cells and antibodies in CNS demyelinating disease

被引：180

作者：

Cross, AH ^{[1
]}

Trotter, JL ^{[1
]}

Lyons, JA ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol & Neurosurg, St Louis, MO 63110 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 112卷 / 1-2期

关键词：

multiple sclerosis; experimental autoimmune encephalomyelitis; B cell; plasma cell; antibody;

D O I：

10.1016/S0165-5728(00)00409-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is much evidence to implicate B cells, plasma cells, and their products in the pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is initiated by myelin-specific T cells, there is accumulating evidence of a role for B cells, plasma cells, and their products in EAE pathogenesis. The role(s) played by B cells, plasma cells, and antibodies in CNS inflammatory demyelinating diseases are likely to be multifactorial and complex, involving distinct and perhaps opposing roles for B cells versus antibody. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 14

页数：14

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