Peptide based drug delivery systems to the brain

被引：24

作者：

Islam, Yamir ^{[1
]}

Leach, Andrew G. ^{[1
,2
]}

Smith, Jayden ^{[3
]}

Pluchino, Stefano ^{[4
,5
]}

Coxonl, Christopher R. ^{[1
,6
]}

Sivakumaran, Muttuswamy ^{[7
]}

Downing, James ^{[1
]}

Fatokun, Amos A. ^{[1
]}

Teixido, Meritxell ^{[8
]}

Ehtezazi, Touraj ^{[1
]}

机构：

[1] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside, England

[2] Univ Manchester, Div Pharm & Optometry, Stopford Bldg Oxford Rd, Manchester M13 9PT, Lancs, England

[3] Cambridge Innovat Technol Consulting CITC Ltd, St Johns Innovat Ctr, Cowley Rd, Cambridge CB4 0WS, England

[4] Univ Cambridge, Dept Clin Neurosci, Clifford Allbutt Bldg,Cambridge Biosci Campus, Cambridge CB2 0HA, England

[5] Univ Cambridge, NIHR Biomed Res Ctr, Hills Rd, Cambridge CB2 0HA, England

[6] Heriot Watt Univ, Sch Engn & Phys Sci, William Perkin Bldg, Edinburgh EH14 4AS, Midlothian, Scotland

[7] Peterborough City Hosp, Dept Haematol, Edith Cavell Campus, Peterborough PE3 9GZ, England

[8] Barcelona Inst Sci & Technol BIST, Inst Res Biomed IRB Barcelona, Baldiri Reixac 10, Barcelona 08028, Spain

来源：

NANO EXPRESS | 2020年 / 1卷 / 01期

关键词：

blood brain barrier; drug delivery; brain; nanoparticles; nanotechnology; shuttle peptides; CENTRAL-NERVOUS-SYSTEM; COLLOIDAL GOLD NANOPARTICLES; RECEPTOR-BINDING DOMAIN; WALLED CARBON NANOTUBES; IN-VITRO; PROTEIN CORONA; TARGETED DELIVERY; SIRNA DELIVERY; CHITOSAN NANOPARTICLES; ALZHEIMERS-DISEASE;

D O I：

10.1088/2632-959X/ab9008

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers and society at large. In the last two decades, numerous strategies and technologies have been developed and adapted to achieve drug penetration into the brain, evolving alongside our understanding of the physiological barriers between the brain and surrounding tissues. The blood brain barrier (BBB) has been known as the major barrier for drug delivery to the brain. Both invasive and minimally-invasive approaches have been investigated extensively, with the minimally-invasive approaches to drug delivery being more suitable. Peptide based brain targeting has been explored extensively in the last two decades. In this review paper, we focused on self-assembled peptides, shuttle peptides and nanoparticles drug delivery systems decorated/conjugated with peptides for brain penetration.

引用

页数：23