Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome

被引:38
作者
Unek, Ilkay Tugba [1 ]
Bayraktar, Firat [2 ]
Solmaz, Dilek [1 ]
Ellidokuz, Hulya [3 ]
Yuksel, Faize [4 ]
Sisman, Ali Riza [5 ]
Yesil, Sena [2 ]
机构
[1] Dokuz Eylul Univ, Dept Internal Med, Sch Med, TR-35340 Izmir, Turkey
[2] Dokuz Eylul Univ, Div Endocrinol & Metab, Sch Med, TR-35340 Izmir, Turkey
[3] Dokuz Eylul Univ, Dept Publ Hlth, Sch Med, TR-35340 Izmir, Turkey
[4] Dokuz Eylul Univ, Div Hematol, Sch Med, TR-35340 Izmir, Turkey
[5] Dokuz Eylul Univ, Dept Biochem, Sch Med, TR-35340 Izmir, Turkey
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2010年 / 59卷 / 03期
关键词
INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; INFLAMMATORY MARKERS; ABDOMINAL OBESITY; COMBINED THERAPY; ANGIOTENSIN-II; BLOOD-PRESSURE; TISSUE FACTOR; WEIGHT-LOSS;
D O I
10.1016/j.metabol.2009.04.034
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The metabolic syndrome (MS) is associated with a systemic inflammatory response that plays an important pathogenetic role in atherothrombotic disease. Increasing evidence indicates that CD40-CD40 ligand interactions constitute an important mediator for vascular inflammation. The purpose of this study was to assess whether high-sensitivity C-reactive protein (hs-CRP) and soluble CD40 ligand (sCD40L) levels were increased in patients with MS. During the study period from January 2004 to August 2004, 312 patients with MS and 98 control subjects were included. Anthropometric measurements, blood pressure assessment, electrocardiography, and blood measurements including fasting blood glucose, postprandial blood glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, glycated hemoglobin, white blood cell (WBC), platelets, hs-CRP, and sCD40L were performed. Patients with MS were divided into 3 groups based upon their glucose tolerance (group 1, normal glucose tolerance; group 2, prediabetic group; and group 3, diabetes mellitus). Patients with MS showed a significant increase of WBC, hs-CRP, and sCD40L levels compared with control subjects. The levels of both hs-CRP and sCD40L were positively correlated with body mass index (BMI). High-sensitivity CRP levels were also positively correlated with waist circumferences, fasting blood glucose, postprandial blood glucose, and glycated hemoglobin, and negatively correlated with high-density lipoprotein cholesterol. In patients with MS, both hs-CRP and sCD40L levels were positively correlated with WBC count. We found a positive correlation between sCD40L and platelets. Among the subgroups of patients with MS, the mean levels of WBC, hs-CRP, and sCD40L did not show any significant differences. In conclusion, elevated levels of WBC, hs-CRP, and sCD40L in MS patients provide further insight into the relationship between MS and inflammation. In our study, positive correlations between BMI and both hs-CRP and sCD40L levels suggest that BMI is an important determinant of a chronic inflammatory state in patients with MS. Moreover, this study reports significantly increased levels of WBC, hs-CRP, and sCD40L not only in diabetic subjects with MS but also in prediabctic subjects and nondiabetic subjects with MS compared with control subjects. Our data suggest that MS patients have proinflammatory state independent of their glucose tolerance status. In our study, the positive correlation between the levels of sCD40L and platelets in patients with MS supports previous reports indicating that sCD40L are derived predominantly from platelets. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:305 / 313
页数:9
相关论文
共 50 条
[31]   The role of C-reactive protein in the metabolic syndrome and diabetes mellitus [J].
Sowers, James R. .
ENDOCRINOLOGIST, 2007, 17 (03) :163-168
[32]   The prognostic value of plasma soluble CD40 ligand levels following aneurysmal subarachnoid hemorrhage [J].
Chen, Xian-Dong ;
Sun, Jun ;
Lu, Chuan ;
Ba, Hua-Jun ;
Chen, Mao-Hua ;
Lin, Jian-Hu ;
Cai, Jian-Yong .
THROMBOSIS RESEARCH, 2015, 136 (01) :24-29
[33]   Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease [J].
Oktem, Mesut ;
Ozcimen, Emel Ebru ;
Uckuyu, Ayla ;
Esinler, Ibrahim ;
Pamuk, Baris ;
Bayraktar, Nilufer ;
Kulaksizoglu, Sevsen ;
Zeyneloglu, Hulusi B. .
FERTILITY AND STERILITY, 2009, 91 (06) :2545-2550
[34]   Impact of metabolic syndrome and C-reactive protein on outcome after coronary stenting [J].
Iturry-Yamamoto, G. R. ;
Zago, A. C. ;
Moriguchi, E. H. ;
Manfroi, W. C. ;
Camargo, J. L. ;
Gross, J. L. ;
Zago, A. J. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2009, 32 (04) :383-386
[35]   Levels of Soluble CD40 Ligand and P-Selectin in Nonalcoholic Fatty Liver Disease [J].
Ercin, Cemal Nuri ;
Dogru, Teoman ;
Tapan, Serkan ;
Karslioglu, Yildirim ;
Haymana, Cem ;
Kilic, Selim ;
Sonmez, Alper ;
Yesilova, Zeki ;
Uygun, Ahmet ;
Gulsen, Mustafa ;
Bagci, Sait ;
Erbil, M. Kemal .
DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (04) :1128-1134
[36]   Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control [J].
F. Cipollone ;
F. Chiarelli ;
G. Davì ;
C. Ferri ;
G. Desideri ;
M. Fazia ;
A. Iezzi ;
F. Santilli ;
B. Pini ;
C. Cuccurullo ;
S. Tumini ;
A. Del Ponte ;
A. Santucci ;
F. Cuccurullo ;
A. Mezzetti .
Diabetologia, 2005, 48 :1216-1224
[37]   Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus:: effect of improved metabolic control [J].
Cipollone, F ;
Chiarelli, F ;
Davì, G ;
Ferri, C ;
Desideri, G ;
Fazia, M ;
Iezzi, A ;
Santilli, F ;
Pini, B ;
Cuccurullo, C ;
Tumini, S ;
Del Ponte, A ;
Santucci, A ;
Cuccurullo, F ;
Mezzetti, A .
DIABETOLOGIA, 2005, 48 (06) :1216-1224
[38]   Soluble CD40 Ligand in Aspirin-Treated Patients Undergoing Cardiac Catheterization [J].
Gremmel, Thomas ;
Frelinger, Andrew L., III ;
Michelson, Alan D. .
PLOS ONE, 2015, 10 (08)
[39]   Soluble CD40 ligand in haemodialysis patients: survival impact and cardiovascular prognostic role [J].
Rusu, Crina ;
Racasan, Simona ;
Moldovan, Diana ;
Kacso, Ina Maria ;
Potra, Alina ;
Bondor, Cosmina Ioana ;
Patiu, Ioan Mihai ;
Vladutiu, Dan ;
Caprioara, Mirela Gherman .
BIOMARKERS, 2017, 22 (3-4) :232-238
[40]   Platelet CD40 contributes to enhanced monocyte chemoattractant protein 1 levels in patients with resistant hypertension [J].
Stumpf, Christian ;
Raaz, Dorette ;
Klinghammer, Lutz ;
Schneider, Markus ;
Schmieder, Roland E. ;
Garlichs, Christoph D. ;
Achenbach, Stephan .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2016, 46 (06) :564-571