Electrochemical behavior of an anticancer drug 5-fluorouracil at methylene blue modified carbon paste electrode

被引：105
作者：
Bukkitgar, Shikandar D. [1 ]
Shetti, Nagaraj P. [1 ]
机构：
[1] Visvesvaraya Technol Univ, Dept Chem, KLE Inst Technol, Belgaum 580030, Karnataka, India
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 65卷
关键词：
5-Fltorouracil; Electrochemical behavior; Reaction mechanism; Methylene blue modified electrode; COMPOSITE POTENTIOMETRIC SENSOR; LOOP DIURETIC FUROSEMIDE; VOLTAMMETRIC DETERMINATION; IMPRINTED POLYMER; GOLD ELECTRODE; ASCORBIC-ACID; IONIC LIQUID; OXIDATION; PERFORMANCE; FILM;
D O I：
10.1016/j.msec.2016.04.045
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A novel sensor for the determination of 5-fluorouracil was constructed by electrochemical deposition of methylene blue on surface of carbon paste electrode. The electrode surface morphology was studied using Atomic force microscopy and XRD. The electrochemical activity of modified electrode was characterized using cyclic voltammetry and differential pulse method. The developed sensor shows impressive enlargement in sensitivity of 5-fluorouracil determination. The peak currents obtained from differential pulse voltammetry was linear with concentration of 5-fluorouracil in the range 4 x 10(-5)-1 x 10(-7) M and detection limit and quantification limit were calculated to be 2.04 nM and 6.18 nM respectively. Further, the sensor was successfully applied in pharmaceutical and biological fluid sample analysis. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：262 / 268
页数：7
相关论文
共 59 条
[1]   New nano-composite potentiometric sensor composed of graphene nanosheets/thionine/molecular wire for nanomolar detection of silver ion in various real samples [J].
Afkhami, Abbas ;
Shirzadmehr, Ali ;
Madrakian, Tayyebeh ;
Bagheri, Hasan .
TALANTA, 2015, 131 :548-555
[2]   Improvement in performance of a hyoscine butylbromide potentiometric sensor using a new nanocomposite carbon paste: a comparison study with polymeric membrane sensor [J].
Afkhami, Abbas ;
Shirzadmehr, Ali ;
Madrakian, Tayyebeh .
IONICS, 2014, 20 (08) :1145-1154
[3]   New Schiff base-carbon nanotube-nanosilica-ionic liquid as a high performance sensing material of a potentiometric sensor for nanomolar determination of cerium(III) ions [J].
Afkhami, Abbas ;
Madrakian, Tayyebeh ;
Shirzadmehr, Ali ;
Tabatabaee, Masoumeh ;
Bagheri, Hasan .
SENSORS AND ACTUATORS B-CHEMICAL, 2012, 174 :237-244
[4]   Validated High-Performance Liquid Chromatographic Technique for Determination of 5-Fluorouracil: Applications to Stability Studies and Simulated Colonic Media [J].
Alanazi, Fars K. ;
Yassin, Alaa Eldeen ;
El-Badry, Mahmoud ;
Mowafy, Hammam A. ;
Alsarra, Ibrahim A. .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2009, 47 (07) :558-563
[5]   Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery:: A comparative study [J].
Arias, Jose L. ;
Adolfina Ruiz, M. ;
Lopez-Viota, Margarita ;
Delgado, Angel V. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2008, 62 (01) :64-70
[6]   Electrochemical study of methylene blue incorporated into mordenite type zeolite and its application for amperometric determination of ascorbic acid in real samples [J].
Arvand, M ;
Sohrabnezhad, S ;
Mousavi, MF ;
Shamsipur, M ;
Zanjanchi, MA .
ANALYTICA CHIMICA ACTA, 2003, 491 (02) :193-201
[7]   Rapid and simultaneous determination of tetracycline and cefixime antibiotics by mean of gold nanoparticles-screen printed gold electrode and chemometrics tools [J].
Asadollahi-Baboli, M. ;
Mani-Varnosfaderani, A. .
MEASUREMENT, 2014, 47 :145-149
[8]   Determination of the 5-fluorouracil and N1(2′-furanidyl)uracil in the presence of tegafur by zero-crossing first derivative spectrometry [J].
Badea, I ;
Moja, D ;
Tudose, A ;
Stoicescu, D .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2002, 30 (04) :1371-1378
[9]   Facile stripping voltammetric determination of haloperidol using a high performance magnetite/carbon nanotube paste electrode in pharmaceutical and biological samples [J].
Bagheri, Hasan ;
Afkhami, Abbas ;
Panahi, Yunes ;
Khoshsafar, Hosein ;
Shirzadmehr, Ali .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2014, 37 :264-270
[10]   Simultaneous electrochemical determination of heavy metals using a triphenylphosphine/MWCNTs composite carbon ionic liquid electrode [J].
Bagheri, Hasan ;
Afkhami, Abbas ;
Khoshsafar, Hosein ;
Rezaei, Mosayeb ;
Shirzadmehr, Ali .
SENSORS AND ACTUATORS B-CHEMICAL, 2013, 186 :451-460
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