SelSim: a program to simulate population genetic data with natural selection and recombination

被引：86

作者：

Spencer, CCA ^{[1
]}

Coop, G ^{[1
]}

机构：

[1] Dept Stat, Oxford OX1 3TG, England

来源：

BIOINFORMATICS | 2004年 / 20卷 / 18期

关键词：

D O I：

10.1093/bioinformatics/bth417

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection.

引用

页码：3673 / 3675

页数：3

共 13 条

[1]

Balding D., 2001, HDB STAT GENETICS, P179, DOI DOI 10.2307/2419615

[2] The effect of selection on genealogies [J].