Magnetic nanoparticles for local drug delivery using magnetic implants

被引：57
作者：
Fernandez-Pacheco, Rodrigo
Marquina, Clara
Gabriel Valdivia, J.
Gutierrez, Martin
Soledad Romero, M.
Cornudella, Rosa
Laborda, Alicia
Viloria, Americo
Higuera, Teresa
Garcia, Alba
Antonio Garcia de Jalon, J.
Ricardo Ibarra, M. [1 ]
机构：
[1] Univ Zaragoza, Inst Univ Invest Nanociencia Aragon, Edif Inter 2, E-50009 Zaragoza, Spain
[2] Univ Zaragoza, CSIC, Fac Ciencias, Inst Ciencia Mat Aragon, E-50009 Zaragoza, Spain
[3] Hosp Clin Univ Lozano Blesa, Zaragoza 50009, Spain
[4] Univ Zaragoza, Fac Vet, Dpto Patol Anim, E-50013 Zaragoza, Spain
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期
关键词：
magnetic nanoparticle; magnetic implant; biocompatibility; local therapy; drug delivery;
D O I：
10.1016/j.jmmm.2006.11.192
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Magnetic nanoparticles are good candidates used for the targeted delivery of anti-tumor agents. They can be concentrated on a desired region, reducing collateral effects and improving the efficiency of the chemotherapy. We propose a method in which permanent magnets are implanted by laparoscopic technique directly in the affected organ. This method proposes the use of Fe@C nanoparticles, which are loaded with doxorubicin and injected intravenously. The particles, once attracted to the magnet, release the drug at the tumor region. This method seems to be more promising and effective than that based on the application of external magnetic fields. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：318 / 322
页数：5
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