Synthesis of Biologically Active Phenoxy Derivatives of Substituted Benzothiazole Organophosphates

被引：8

作者：

Jhajharia, Priyanka ^{[1
]}

Samota, Mahesh Kumar ^{[1
]}

Seth, Gita ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

HETEROATOM CHEMISTRY | 2010年 / 21卷 / 02期

关键词：

ONE-POT SYNTHESIS; IN-VIVO; INHIBITORS;

D O I：

10.1002/hc.20582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of S-(phenyl benzothiazolyl-2)phosphorodichloridothioate/phosphorodichloridodithioate with 2 mol of phenol/4-chlorophenol/4-nitrophenol in the presence of stoichiometric amounts of triethylamine in dry THF/CH(2)Cl(2) has afforded a series of the corresponding organophosphate phenoxy derivatives (1a, 1b, 2a, 2b, and 3a, 3b). Plausible structures have been proposed on the basis of elemental analysis, IR, (1)H NMR, (31)P NMR, and mass spectral studies. The antibacterial activity of these organophosphate phenoxy derivatives has been evaluated against pathogenic bacteria Staphylococcus aureus (+ve) and Escherichia coli (-ve). The antifungal activity of these organophosphate phenoxy derivatives has been evaluated against pathogenic fungi Aspergillus niger and Fusarium oxysporium. The results indicate that organophosphate phenoxy derivatives are found more active than the parent compounds. (C) 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:8488, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20582

引用

页码：84 / 88

页数：5

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