A Cascade Phosphinoylation/Cyclization/Desulfonylation Process for the Synthesis of 3-Phosphinoylindoles

被引：89

作者：

Gao, Yuzhen ^{[1
,2
]}

Lu, Guozhang ^{[1
,2
]}

Zhang, Pengbo ^{[1
,2
]}

Zhang, Liangliang ^{[1
,2
]}

Tang, Guo ^{[1
,2
]}

Zhao, Yufen ^{[1
,2
,3
]}

机构：

[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China

[3] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 06期

关键词：

REDUCTIVE CLEAVAGE; AEROBIC OXYPHOSPHORYLATION; CATALYZED CYCLIZATION; PRACTICAL SYNTHESIS; C-P; ALKYNES; FUNCTIONALIZATION; SULFONAMIDES; DERIVATIVES; ARYLATION;

D O I：

10.1021/acs.orglett.6b00056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Phosphinoylindole derivatives play important roles as pharmaceutical drugs and ligands. A new method for the synthesis of 3-phosphinoylindole derivatives has been achieved through silver-mediated cycloaddition between N-Ts-2-alkynylaniline derivatives and H-phosphine oxides. This transformation offers a straightforward route to the formation of the C-P bond, indole ring, and desulfonylation in one step.

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页码：1242 / 1245

页数：4

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