Systematical synthesis of distamycin analogues and their interaction with herring sperm DNA

被引：6

作者：

Tang, FL ^{[1
]}

Wang, J ^{[1
]}

Liu, D ^{[1
]}

Li, JJ ^{[1
]}

Yuan, G ^{[1
]}

机构：

[1] Peking Univ, Coll Chem, Dept Biol Chem, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2002年 / 49卷 / 06期

关键词：

distamycin; synthesis; chloroform reaction; fluorescence; DNA;

D O I：

10.1002/jccs.200200155

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple procedure for the systematical synthesis of eight distamycin analogues containing N-methyl-pyrrole (Py) and N-methylimidazole (Im) has been developed by a chloroform reaction and DCC coupling reaction without amino protection and deprotection, and the interaction of the analogues with Herring Sperm DNA was investigated by fluorescence spectroscopy.

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收藏

页码：1073 / 1077

页数：5

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