Pericytes at the intersection between tissue regeneration and pathology

被引：185

作者：

Birbrair, Alexander ^{[1
,2
]}

Zhang, Tan ^{[1
]}

Wang, Zhong-Min ^{[1
]}

Messi, Maria Laura ^{[1
]}

Mintz, Akiva ^{[3
]}

Delbono, Osvaldo ^{[1
,2
]}

机构：

[1] Wake Forest Sch Med, Dept Internal Med Gerontol, Winston Salem, NC 27157 USA

[2] Wake Forest Sch Med, Neurosci Program, Winston Salem, NC 27157 USA

[3] Wake Forest Sch Med, Dept Neurosurg, Winston Salem, NC 27157 USA

来源：

CLINICAL SCIENCE | 2015年 / 128卷 / 02期

基金：

美国国家卫生研究院;

关键词：

injury; pericyte; regeneration; stem cell; MESENCHYMAL STEM-CELLS; HEPATIC STELLATE CELLS; VASCULAR SMOOTH-MUSCLE; HUMAN BRAIN PERICYTES; COLLAGEN-PRODUCING CELLS; PDGF BETA-RECEPTOR; FAT-STORING CELLS; SKELETAL-MUSCLE; MICROVASCULAR PERICYTES; PERIVASCULAR CELLS;

D O I：

10.1042/CS20140278

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Perivascular multipotent cells, pericytes, contribute to the generation and repair of various tissues in response to injury. They are heterogeneous in their morphology, distribution, origin and markers, and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support the concept that pericyte subtypes play a distinctive role in myogenesis, neurogenesis, adipogenesis, fibrogenesis and angiogenesis.

引用

页码：81 / 93

页数：13

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