Treatment of adult-onset Still's disease: a review

被引：80

作者：

Jamilloux, Yvan ^{[1
,2
,3
]}

Gerfaud-Valentin, Mathieu ^{[1
]}

Henry, Thomas ^{[3
]}

Seve, Pascal ^{[1
]}

机构：

[1] Univ Lyon 1, Hop Croix Rousse, Dept Internal Med, Lyon, France

[2] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

[3] Univ Lyon 1, INSERM U1111, Internat Res Ctr Infectiol, Lyon, France

来源：

THERAPEUTICS AND CLINICAL RISK MANAGEMENT | 2015年 / 11卷

关键词：

adult-onset Still's disease; treatment; anakinra; tocilizumab; canakinumab; JUVENILE IDIOPATHIC ARTHRITIS; MACROPHAGE ACTIVATION SYNDROME; THROMBOTIC THROMBOCYTOPENIC PURPURA; OF-THE-LITERATURE; INTERLEUKIN-1 RECEPTOR ANTAGONIST; REACTIVE HEMOPHAGOCYTIC SYNDROME; TUMOR-NECROSIS-FACTOR; INTRAVENOUS IMMUNOGLOBULIN; RHEUMATOID-ARTHRITIS; CYTOKINE PROFILES;

D O I：

10.2147/TCRM.S64951

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Adult-onset Still's disease (AOSD) is a rare inflammatory disorder that has been recently classified as a polygenic autoinflammatory disorder. The former classification, based on the disease course, seems to be quite dated. Indeed, there is accumulating evidence that AOSD can be divided into two distinct phenotypes based on cytokine profile, clinical presentation, and outcome, ie, a "systemic" pattern and an "articular" pattern. The first part of this review deals with the treatments that are currently available for AOSD. We then present the different strategies based on the characteristics of the disease according to clinical presentation. To do so, we focus on the two subsets of the disease. Finally, we discuss the management of life-threatening complications of AOSD, along with the therapeutic options during pregnancy.

引用

页码：33 / 43

页数：11

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