Temperature-dependence of the solubility of some acetanilide derivatives in several organic and aqueous solvents

被引：33

作者：

Baena, Y

Pinzón, JA

Barbosa, HJ

Martínez, F ^{[1
]}

机构：

[1] Univ Nacl Colombia, Dept Pharm, Bogota 14490, Colombia

[2] Univ Nacl Colombia, Dept Chem, Bogota 14490, Colombia

来源：

PHYSICS AND CHEMISTRY OF LIQUIDS | 2004年 / 42卷 / 06期

关键词：

acetanilide; acetaminophen; phenacetin; solubility; activity coefficients;

D O I：

10.1080/00319100412331284413

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The thermodynamic functions free energy, enthalpy, and entropy of solution, were evaluated from the solubility data of acetanilide, acetaminophen, and phenacetin, determined at several temperatures in water, octanol, isopropyl myristate, and chloroform. These three organic Solvents Mutually saturated with water, and finally. in cyclohexane. In the aqueous media, the solubility was determined at pH 7.4 and ionic strength 0.15 mol L-1. The excess free energy and the activity coefficients of the solutes were also determined. The solubility for acetanilide and phenacetin was higher in organic media Such as octanol and chloroform than is those obtained in the aqueous media and cyclohexane, while for acetaminophen the solubility was higher in octanol than those obtained in the other solvents.

引用

页码：603 / 613

页数：11

共 32 条

[1] THERMODYNAMICS OF AQUEOUS-SOLUTIONS OF PARABENS [J].