A NEW METHOD FOR MEASURING THE SPEED OF SOUND IN RAT LIVER EX VIVO USING AN ULTRASOUND SYSTEM: CORRELATION OF SOUND SPEED WITH FAT DEPOSITION

被引:18
作者
Kumagai, Hideki [1 ]
Yokoyama, Koji [1 ]
Katsuyama, Kimito [2 ]
Hara, Shoji [2 ]
Yamamoto, Hiroaki [2 ]
Yamagata, Takanori [1 ]
Taniguchi, Nobuyuki [3 ]
Hirota, Norio [4 ]
Itoh, Kouichi [5 ]
机构
[1] Jichi Med Univ, Dept Pediat, Shimotsuke, Tochigi 3290498, Japan
[2] Fujifilm Corp, Imaging Technol Ctr, R&D Management Headquarters, Tokyo, Japan
[3] Jichi Med Univ, Dept Clin Lab Med, Shimotsuke, Tochigi 3290498, Japan
[4] Hirota Surg Pathol Inst, Shimotsuke, Tochigi, Japan
[5] Hitachiomiya Saiseikai Hosp, Hitachiomiya, Ibaraki, Japan
关键词
Fatty liver; Non-invasive diagnosis; Pulser-receiver; Rat; Speed measurement; Speed of sound; Steatosis; Tissue characterization; Ultrasonics; Ultrasound; BIOLOGICAL TISSUES; DISEASE; PROPAGATION; STEATOHEPATITIS; ATTENUATION; STEATOSIS; DIAGNOSIS; VELOCITY; SPLEEN;
D O I
10.1016/j.ultrasmedbio.2014.03.019
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
The speed of sound correlates well with the fat content of the liver. Therefore, non-invasive quantification of sound speed in the liver might be of diagnostic value. Here we describe a new non-invasive method that would be clinically applicable for measurement of sound speed in the liver. Sprague-Dawley rats were divided into two groups: a control group and a fatty liver group prepared by keeping the rats on a choline-deficient diet for 6 wk. The livers were subjected to pathologic and biochemical analysis; the speed of sound through the liver tissue was measured using our proposed method and a pulser-receiver as standard. Our results indicated that use of the proposed method makes it feasible to diagnose fatty liver with good accuracy on the basis of sound speed. This approach would have considerable potential for non-invasive diagnosis of fatty liver and would be a valuable adjunct to conventional liver diagnostic procedures. (C) 2014 World Federation for Ultrasound in Medicine & Biology.
引用
收藏
页码:2499 / 2507
页数:9
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