Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma

被引：9
作者：
Niedobitek, G [1 ]
机构：
[1] Univ Erlangen Nurnberg, Inst Pathol, D-91054 Erlangen, Germany
来源：
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2000年 / 53卷 / 05期
关键词：
Epstein-Barr virus; nasopharyngeal carcinoma; viral latent gene expression;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The association of nasopharyngeal carcinoma (NPC) with the Epstein-Barr virus (EBV) was firmly established as early as 1973. Nevertheless. the role for the virus in the pathogenesis of NPC is still controversial. In this article, the evidence implicating EBV in the development of NPC is reviewed, focusing on the cellular site of EBV persistence, the association of the virus with different NPC histotypes, the tumour cell phenotype in the context of viral latent gene expression, and the possible role of the lymphoid stroma.
引用
收藏
页码：248 / 254
页数：7
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