Chemokines and the extracellular matrix: Set of targets for tumor development and treatment

被引：23

作者：

da Silva, Paulo Henrique Rosa ^{[1
]}

Borges, Bruna Cristina ^{[1
]}

Uehara, Isadora Akemi ^{[1
]}

Soldi, Luiz Ricardo ^{[1
]}

de Araujo, Rogerio Agenor ^{[1
]}

Silva, Marcelo Jose Barbosa ^{[1
]}

机构：

[1] Univ Fed Uberlandia, Inst Biomed Sci, Lab Tumor Biomarkers & Osteoimmunol, Uberlandia, MG, Brazil

来源：

CYTOKINE | 2021年 / 144卷

关键词：

Chemokines; Tumor; Extracellular matrix; Recruitment; Adherence; Progress; HEPARAN-SULFATE PROTEOGLYCANS; CELL LUNG-CANCER; CC-CHEMOKINE; GLYCOSAMINOGLYCAN-BINDING; T-CELLS; INFLAMMATORY CHEMOKINES; MONOCLONAL-ANTIBODY; ANTITUMOR IMMUNITY; LIGAND; IN-VIVO;

D O I：

10.1016/j.cyto.2021.155548

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extracellular matrix (ECM) consists of various molecules that support tissue cells, including proteins, fibronectin, laminin, collagen IV, and glycosaminoglycans. In addition to interactions between the ECM and cells, the ECM also interacts with chemokines, and growth factors, and these interactions ensure cell survival, development, differentiation, and migration of both immune system cells and tumor cells. This review provides an overview of the mechanisms of interaction between the ECM and chemokines, focusing on the tumor microenvironment and the modulation of these elements as a target for therapies in several types of cancer.

引用

页数：9

共 105 条

[1]

AC H., 2019, SYSTEMATIC REV, DOI [10.21203/RS.2.11557/V1, DOI 10.21203/RS.2.11557/V1]

[2] Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis [J].

Adekoya, Timothy O. ;

Richardson, Ricardo M. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12) :1-29

[3] A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation [J].

Ali, S ;

Robertson, H ;

Wain, JH ;

Isaacs, JD ;

Malik, G ;

Kirby, JA .

JOURNAL OF IMMUNOLOGY, 2005, 175 (02) :1257-1266

[4] Therapy with Nonglycosaminoglycan-Binding Mutant CCL7: A Novel Strategy to Limit Allograft Inflammation [J].

Ali, S. ;

O'Boyle, G. ;

Hepplewhite, P. ;

Tyler, J. R. ;

Robertson, H. ;

Kirby, J. A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (01) :47-58

[5]

[Anonymous], Definition of CCR2/CCR5 antagonist BMS-813160-NCI Drug Dictionary.

[6] Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines [J].

Arenberg, DA ;

Keane, MP ;

DiGiovine, B ;

Kunkel, SL ;

Strom, SRB ;

Burdick, MD ;

Iannettoni, MD ;

Strieter, RM .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2000, 49 (02) :63-70

[7] Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties [J].

Augsten, Martin ;

Sjoberg, Elin ;

Frings, Oliver ;

Vorrink, Sabine U. ;

Frijhoff, Jeroen ;

Olsson, Eleonor ;

Borg, Ake ;

Ostman, Arne .

CANCER RESEARCH, 2014, 74 (11) :2999-3010

[8] CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth [J].

Augsten, Martin ;

Hagglof, Christina ;

Olsson, Eleonor ;

Stolz, Claudia ;

Tsagozis, Panagiotis ;

Levchenko, Tetyana ;

Frederick, Mitchell J. ;

Borg, Ake ;

Micke, Patrick ;

Egevad, Lars ;

Ostman, Arne .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3414-3419

[9] Chemokines: more than just road signs [J].

Bachmann, MF ;

Kopf, M ;

Marsland, BJ .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (02) :159-164

[10] Cancer and the chemokine network [J].

Balkwill, F .

NATURE REVIEWS CANCER, 2004, 4 (07) :540-550

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