Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR

被引：135
作者：
Handschin, C
Meyer, UA
机构：
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Cell Biol, Boston, MA 02115 USA
[2] Univ Basel, Biozentrum, Div Pharmacol Neurobiol, CH-4056 Basel, Switzerland
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2005年 / 433卷 / 02期
关键词：
nuclear receptors; drug-induction; lipids; bile acids; cholesterol; CAR; PXR; LXR; FXR; cytochrome P450;
D O I：
10.1016/j.abb.2004.08.030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cloning and characterization of the orphan nuclear receptors Constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) led to major breakthroughs in Studying drug-mediated transcriptional induction of drug-metabolizing cytochromes P450 (CYPs). More recently, additional roles for CAR and PXR have been discovered. As examples, these xenosensors are involved in the homeostasis of cholesterol, bile acids, bilirubin, and other endogenous hydrophobic molecules in the liver: CAR and PXR thus form an intricate regulatory network with other members of the nuclear receptor superfamily, foremost the cholesterol-sensing liver X receptor (LXR, NR1H2/3) and the bile-acid-activated farnesoid X receptor (FXR, NR1H4). In this review, functional interactions between these nuclear receptors as well as the consequences on physiology and pathophysiology of the liver are discussed. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：387 / 396
页数：10
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