Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism

被引：42

作者：

Kypson, AP

Morphew, E

Jones, R

Gottfried, MR

Seigler, HF

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2003年 / 82卷 / 02期

关键词：

bone morphogenic protein; rectal adenocarcinoma; ossification;

D O I：

10.1002/jso.10181

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.

引用

页码：132 / 136

页数：5

共 36 条

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Alper M, 2000, SCAND J GASTROENTERO, V35, P556

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