One-Pot Desulfonylative Alkylation of N-Sulfonyl Azacycles Using Alkoxides Generated by Phase-Transfer Catalysis

被引：11

作者：

Denton, Justin R. ^{[1
]}

机构：

[1] Obiter Res, Chem Res & Proc Dev, Champaign, IL 61822 USA

来源：

SYNTHESIS-STUTTGART | 2010年 / 05期

关键词：

phase-transfer catalysis; sulfonamides; heterocycles; cleavage; alkylation; CANNABIMIMETIC INDOLES; DERIVATIVES; INHIBITORS; ACTIVATION; ACYLATION; ALCOHOLS; RECEPTOR; DESIGN;

D O I：

10.1055/s-0029-1218627

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sulfonamide heterocycles, specifically 3-acylindoles, undergo a deprotection/alkylation sequence in the presence of an appropriate alcohol when cesium carbonate or potassium carbonate and a phase-transfer catalyst are utilized. The outcome of the one-pot protocol was found to be significantly dependent on both the alcohol and sulfonamide heterocycle employed. Strictly anhydrous conditions are not necessary for this protocol.

引用

页码：775 / 782

页数：8

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