The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer

被引：42

作者：

Ohta, M ^{[1
]}

Konno, H ^{[1
]}

Tanaka, T ^{[1
]}

Baba, M ^{[1
]}

Kamiya, K ^{[1
]}

Syouji, T ^{[1
]}

Kondoh, K ^{[1
]}

Watanabe, M ^{[1
]}

Terada, H ^{[1
]}

Nakamura, S ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 4313192, Japan

来源：

CANCER LETTERS | 2003年 / 192卷 / 02期

关键词：

vascular endothelial growth factor; gastric cancer; lymph nodes;

D O I：

10.1016/0304-3835(02)00681-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the vascular endothelial growth factor (VEGF) levels in peripheral blood and drainage vein (plasma and serum), and then these were compared with local VEGF expression from gastric cancer. Peripheral blood plasma VEGF levels was increased in the patients with venous invasion, and moderately correlated with the number and ratio of lymph nodes with metastasis. Local VEGF expression was correlated significantly with tumor size, advanced stage and lymph node metastasis, but not correlated with peripheral VEGF levels. The level of plasma VEGF in peripheral veins is one of the sensitive markers of the status of gastric cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：215 / 225

页数：11

共 52 条

[1]

Adams J, 2000, CANCER RES, V60, P2898

[2] Relationship of p53 and vascular endothelial growth factor expression to clinicopathological factors in human scirrhous gastric cancer [J].

Baba, M ;

Konno, H ;

Maruo, Y ;

Tanaka, T ;

Kanai, T ;

Matsumoto, K ;

Matsuura, M ;

Nishino, N ;

Maruyama, K ;

Nakamura, S ;

Baba, S .

EUROPEAN SURGICAL RESEARCH, 1998, 30 (02) :130-137

[3] Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology [J].

Banks, RE ;

Forbes, MA ;

Kinsey, SE ;

Stanley, A ;

Ingham, E ;

Walters, C ;

Selby, PJ .

BRITISH JOURNAL OF CANCER, 1998, 77 (06) :956-964

[4]

BROWN LF, 1993, AM J PATHOL, V143, P1255

[5]

BROWN LF, 1993, CANCER RES, V53, P4727

[6] Pre-operative serum vascular endothelial growth factor can select patients for adjuvant treatment after curative resection in colorectal cancer [J].

Chin, KF ;

Greenman, J ;

Gardiner, E ;

Kumar, H ;

Topping, K ;

Monson, J .

BRITISH JOURNAL OF CANCER, 2000, 83 (11) :1425-1431

[7]

Davies MM, 2000, BRIT J CANCER, V82, P1004

[8]

Dirix LY, 1996, ANN ONCOL, V7, P843

[9] Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients [J].

Dirix, LY ;

Vermeulen, PB ;

Pawinski, A ;

Prove, A ;

Benoy, I ;

DePooter, C ;

Martin, M ;

VanOosterom, AT .

BRITISH JOURNAL OF CANCER, 1997, 76 (02) :238-243

[10]

DVORAK HF, 1995, AM J PATHOL, V146, P1029

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