Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3'-untranslated region of the prothrombin gene

被引：144

作者：

Brown, K ^{[1
]}

Luddington, R ^{[1
]}

Williamson, D ^{[1
]}

Baker, P ^{[1
]}

Baglin, T ^{[1
]}

机构：

[1] ADDENBROOKES NHS TRUST,DEPT HAEMATOL,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 04期

关键词：

thrombosis; embolism; thrombophilia; prothrombin gene;

D O I：

10.1046/j.1365-2141.1997.3093130.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The odds ratio for the FII 20210G/A mutation in 504 patients with venous thromboembolism compared to controls was 2.0 (95% Cl 1.0-4.0) and, for factor V Leiden, 5.8 (95% CI 3.3-10.3). 3/504 patients were heterozygous for both mutations, None of the patients had combined natural anticoagulant deficiency and the FII 20210G/A mutation. We conclude that the FII 20210G/A mutation is present in 2.6% of the population and the relative risk of venous thromboembolism in carriers is 2.0.

引用

页码：907 / 909

页数：3

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