Imidazole libraries on solid support

被引：171

作者：

Sarshar, S ^{[1
]}

Siev, D ^{[1
]}

Mjalli, AMM ^{[1
]}

机构：

[1] ONTOGEN CORP,CARLSBAD,CA 92009

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 06期

关键词：

D O I：

10.1016/0040-4039(95)02334-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The method of synthesis of highly substituted imidazole libraries on solid support using an aldehyde, an amine and a 1,2-dione in the presence of NH4OAc is described. The synthesis was accomplished by attaching the aldehyde or amine component to Wang resin via ester or ether linkages. A class of unsymmetrical bis-imidazoles has also been prepared without any need for selective protection of the synthetic intermediates.

引用

收藏

页码：835 / 838

页数：4

相关论文

共 23 条

[1] AN ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE-BOND REPLACEMENT - CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS [J].

ABDELMEGUID, SS ;

METCALF, BW ;

CARR, TJ ;

DEMARSH, P ;

DESJARLAIS, RL ;

FISHER, S ;

GREEN, DW ;

IVANOFF, L ;

LAMBERT, DM ;

MURTHY, KHM ;

PETTEWAY, SR ;

PITTS, WJ ;

TOMASZEK, TA ;

WINBORNE, E ;

ZHAO, BG ;

DREYER, GB ;

MEEK, TD .

BIOCHEMISTRY, 1994, 33 (39) :11671-11677

[2]

ANGIOTENSIN II, 1995, BIORG MED CHEM LETT, V5, P19

[3]

ARMSTRONG RW, 1995, Patent No. 95192566

[4] POLYMER-SUPPORTED SYNTHESIS OF 2,5-DISUBSTITUTED TETRAHYDROFURANS [J].

BEEBE, X ;

SCHORE, NE ;

KURTH, MJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (25) :10061-10062

[5]

Brodgen RN, 1978, DRUGS, V15, P93

[6] THE COMBINATORIAL SYNTHESIS AND CHEMICAL AND BIOLOGICAL EVALUATION OF A 1,4-BENZODIAZEPINE LIBRARY [J].

BUNIN, BA ;

PLUNKETT, MJ ;

ELLMAN, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4708-4712

[7] 9-FLUORENYLMETHOXYCARBONYL AMINO-PROTECTING GROUP [J].

CARPINO, LA ;

HAN, GY .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (22) :3404-&

[8] SOLID-PHASE PEPTIDE-SYNTHESIS UTILIZING 9-FLUORENYLMETHOXYCARBONYL AMINO-ACIDS [J].

FIELDS, GB ;

NOBLE, RL .

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1990, 35 (03) :161-214

[9]

GANELLIN CR, 1985, MED CHEM ROLE ORGANI, P93

[10] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS [J].

GORDON, EM ;

BARRETT, RW ;

DOWER, WJ ;

FODOR, SPA ;

GALLOP, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1385-1401