Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampal-prefrontal cortex dysconnectivity

被引：92
作者：
Sampath, Dayalan [1 ]
Sathyanesan, Monica [1 ,2 ]
Newton, Samuel S. [1 ,2 ]
机构：
[1] Univ South Dakota, Sanford Sch Med, Div Basic Biomed Sci, Room 130,Lee Med Bldg,414 East Clark St, Vermillion, SD 57069 USA
[2] Sioux Falls VA Healthcare Syst, Sioux Falls, SD USA
来源：
NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2017年 / 13卷
关键词：
hippocampus; prefrontal cortex; cognition; depression; Alzheimer's disease; ELEMENT-BINDING PROTEIN; CIRCUIT-SPECIFIC ALTERATIONS; FUNCTIONAL CONNECTIVITY; AUTOBIOGRAPHICAL MEMORY; DENTATE GYRUS; VENTRAL HIPPOCAMPUS; APOLIPOPROTEIN-E; FRONTAL-CORTEX; VOLUME LOSS; BRAIN;
D O I：
10.2147/NDT.S136122
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer's disease and depression.
引用
收藏
页码：1509 / 1519
页数：11
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