Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women

被引：45

作者：

Dallmann, Andre ^{[1
]}

Solodenko, Juri ^{[2
]}

Ince, Ibrahim ^{[2
]}

Eissing, Thomas ^{[2
]}

机构：

[1] Univ Childrens Hosp Basel UKBB, Dept Pediat Clin Pharmacol, Basel, Switzerland

[2] Bayer AG, Clin Pharmacometr, Leverkusen, Germany

来源：

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2018年 / 7卷 / 07期

关键词：

PHARMACOKINETIC MODEL; TISSUE DISTRIBUTION; DRUGS; METRONIDAZOLE; PREDICTION; PHYSIOLOGY; CODEINE;

D O I：

10.1002/psp4.12300

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This tutorial presents the workflow of adapting an adult physiologically based pharmacokinetic (PBPK) model to the pregnant populations using the Open Systems Pharmacology (OSP) software suite (www.open-systems-pharmacology.org). This workflow is illustrated using a previously published PBPK model for metronidazole that is extrapolated to pregnancy by parameterizing and extending the model structure in terms of pregnancy-induced physiological changes. Importantly, this workflow can be applied to other scenarios where PBPK models need to be re-parameterized or structurally modified.

引用

页码：419 / 431

页数：13

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