Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women

被引:45
作者
Dallmann, Andre [1 ]
Solodenko, Juri [2 ]
Ince, Ibrahim [2 ]
Eissing, Thomas [2 ]
机构
[1] Univ Childrens Hosp Basel UKBB, Dept Pediat Clin Pharmacol, Basel, Switzerland
[2] Bayer AG, Clin Pharmacometr, Leverkusen, Germany
关键词
PHARMACOKINETIC MODEL; TISSUE DISTRIBUTION; DRUGS; METRONIDAZOLE; PREDICTION; PHYSIOLOGY; CODEINE;
D O I
10.1002/psp4.12300
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This tutorial presents the workflow of adapting an adult physiologically based pharmacokinetic (PBPK) model to the pregnant populations using the Open Systems Pharmacology (OSP) software suite (www.open-systems-pharmacology.org). This workflow is illustrated using a previously published PBPK model for metronidazole that is extrapolated to pregnancy by parameterizing and extending the model structure in terms of pregnancy-induced physiological changes. Importantly, this workflow can be applied to other scenarios where PBPK models need to be re-parameterized or structurally modified.
引用
收藏
页码:419 / 431
页数:13
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