Recent progress in small-molecule inhibitors for critical therapeutic targets of necroptosis

被引：6

作者：

Fang, Zhennan ^{[1
]}

Wei, Huiqiang ^{[1
]}

Gou, Wenfeng ^{[1
]}

Chen, Leyuan ^{[1
]}

Bi, Changfen ^{[1
]}

Hou, Wenbin ^{[1
]}

Li, Yiliang ^{[1
]}

机构：

[1] Peking Union Med Coll & Chinese Acad Med Sci, Beijing, Peoples R China

来源：

FUTURE MEDICINAL CHEMISTRY | 2021年 / 13卷 / 09期

关键词：

co-crystal structures; inhibitors; MLKL; necroptosis; RIPK1; RIPK3;

D O I：

10.4155/fmc-2020-0386

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nonapoptotic types of regulated cell death have attracted widespread interest since the discovery that certain forms of cell necrosis can be regulated. In particular, research into cell necroptosis has made significant progress in connection with kidney, inflammatory, degenerative and neoplastic diseases. Inhibitors targeting the critical necroptosis-associated proteins RIPK1/3 and MLKL have been in development for more than a decade. Herein the authors compile a list of the known small-molecule inhibitors of these enzymes and representative structures of compounds co-crystallized with these proteins and put forward some thoughts regarding their future development.

引用

页码：817 / 838

页数：22

共 83 条

[1]

[Anonymous], 2006, PRACT NEUROL, DOI DOI 10.1136/JNNP.2006.101287

[2] Survey of Glyphosate- and Imazapic-Resistant Palmer Amaranth (Amaranthus palmeri) in Florida [J].

Berger, Sarah T. ;

Ferrell, Jason A. ;

Dittmar, Peter J. ;

Leon, Ramon .

CROP FORAGE & TURFGRASS MANAGEMENT, 2015, 1 (01)

[3] Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death [J].

Boldin, MP ;

Goncharov, TM ;

Goltsev, YV ;

Wallach, D .

CELL, 1996, 85 (06) :803-815

[4] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis [J].

Cai, Zhenyu ;

Jitkaew, Siriporn ;

Zhao, Jie ;

Chiang, Hsueh-Cheng ;

Choksi, Swati ;

Liu, Jie ;

Ward, Yvona ;

Wu, Ling-gang ;

Liu, Zheng-Gang .

NATURE CELL BIOLOGY, 2014, 16 (01) :55-+

[5] Programmed Necrosis in the Cross Talk of Cell Death and Inflammation [J].

Chan, Francis Ka-Ming ;

Luz, Nivea Farias ;

Moriwaki, Kenta .

ANNUAL REVIEW OF IMMUNOLOGY VOL 33, 2015, 33 :79-106

[6] Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3 [J].

Chen, Xiaofei ;

Zhuang, Chunlin ;

Ren, Yibin ;

Zhang, Hao ;

Qin, Xia ;

Hu, Longmiao ;

Fu, Jing ;

Miao, Zhenyuan ;

Chai, Yifeng ;

Li, Zheng-gang ;

Zhang, Haibing ;

Cai, Zhenyu ;

Wang, Hong-yang .

BRITISH JOURNAL OF PHARMACOLOGY, 2019, 176 (12) :2095-2108

[7] Design, synthesis and selection of DNA-encoded small-molecule libraries [J].

Clark, Matthew A. ;

Acharya, Raksha A. ;

Arico-Muendel, Christopher C. ;

Belyanskaya, Svetlana L. ;

Benjamin, Dennis R. ;

Carlson, Neil R. ;

Centrella, Paolo A. ;

Chiu, Cynthia H. ;

Creaser, Steffen P. ;

Cuozzo, John W. ;

Davie, Christopher P. ;

Ding, Yun ;

Franklin, G. Joseph ;

Franzen, Kurt D. ;

Gefter, Malcolm L. ;

Hale, Steven P. ;

Hansen, Nils J. V. ;

Israel, David I. ;

Jiang, Jinwei ;

Kavarana, Malcolm J. ;

Kelley, Michael S. ;

Kollmann, Christopher S. ;

Li, Fan ;

Lind, Kenneth ;

Mataruse, Sibongile ;

Medeiros, Patricia F. ;

Messer, Jeffrey A. ;

Myers, Paul ;

O'Keefe, Heather ;

Oliff, Matthew C. ;

Rise, Cecil E. ;

Satz, Alexander L. ;

Skinner, Steven R. ;

Svendsen, Jennifer L. ;

Tang, Lujia ;

van Vloten, Kurt ;

Wagner, Richard W. ;

Yao, Gang ;

Zhao, Baoguang ;

Morgan, Barry A. .

NATURE CHEMICAL BIOLOGY, 2009, 5 (09) :647-654

[8] Parthanatos, a messenger of death [J].

David, Karen Kate ;

Andrabi, Shaida Ahmad ;

Dawson, Ted Murray ;

Dawson, Valina Lynn .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 :1116-1128

[9] Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury [J].

Degterev A. ;

Huang Z. ;

Boyce M. ;

Li Y. ;

Jagtap P. ;

Mizushima N. ;

Cuny G.D. ;

Mitchison T.J. ;

Moskowitz M.A. ;

Yuan J. .

Nature Chemical Biology, 2005, 1 (2) :112-119

[10] Identification of RIP1 kinase as a specific cellular target of necrostatins [J].

Degterev, Alexei ;

Hitomi, Junichi ;

Germscheid, Megan ;

Ch'en, Irene L. ;

Korkina, Olga ;

Teng, Xin ;

Abbott, Derek ;

Cuny, Gregory D. ;

Yuan, Chengye ;

Wagner, Gerhard ;

Hedrick, Stephen M. ;

Gerber, Scott A. ;

Lugovskoy, Alexey ;

Yuan, Junying .

NATURE CHEMICAL BIOLOGY, 2008, 4 (05) :313-321

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