Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking

被引：16

作者：

Lv, Cheng ^{[1
,2
]}

Lin, Yi ^{[1
,2
]}

Sun, En-Ze ^{[1
,2
]}

Tang, Bo ^{[1
,2
]}

Ao, Jian ^{[1
,2
]}

Wang, Jia-Jia ^{[1
,2
]}

Zhang, Zhi-Ling ^{[1
,2
]}

Zheng, Zhenhua ^{[3
]}

Wang, Hanzhong ^{[3
]}

Pang, Dai-Wen ^{[1
,2
]}

机构：

[1] Wuhan Univ, Key Lab Analyt Chem Biol & Med, Minist Educ, Coll Chem & Mol Sci,State Key Lab Virol,Inst Adv, Wuhan, Hubei, Peoples R China

[2] Wuhan Univ, Wuhan Inst Biotechnol, Wuhan, Hubei, Peoples R China

[3] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 79期

关键词：

ENDOCYTIC PATHWAY; ENTRY; CELLS; MEMBRANE; ROLES; PH;

D O I：

10.1039/c8cc05614e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With the aid of the single-virus tracking technique and the quantum dot-labeling strategy, the internalization of the pseudorabies virus (PrV) has been visualized in real time. The results demonstrate that macropinocytosis can be considered as a major pathway for PrV entering HeLa cells, which facilitates the development of therapeutics for virus-triggered diseases.

引用

页码：11184 / 11187

页数：4