Internalization of the pseudorabies virus via macropinocytosis analyzed by quantum dot-based single-virus tracking

被引：16
|
作者：
Lv, Cheng [1 ,2 ]
Lin, Yi [1 ,2 ]
Sun, En-Ze [1 ,2 ]
Tang, Bo [1 ,2 ]
Ao, Jian [1 ,2 ]
Wang, Jia-Jia [1 ,2 ]
Zhang, Zhi-Ling [1 ,2 ]
Zheng, Zhenhua [3 ]
Wang, Hanzhong [3 ]
Pang, Dai-Wen [1 ,2 ]
机构：
[1] Wuhan Univ, Key Lab Analyt Chem Biol & Med, Minist Educ, Coll Chem & Mol Sci,State Key Lab Virol,Inst Adv, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ, Wuhan Inst Biotechnol, Wuhan, Hubei, Peoples R China
[3] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 79期
关键词：
ENDOCYTIC PATHWAY; ENTRY; CELLS; MEMBRANE; ROLES; PH;
D O I：
10.1039/c8cc05614e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
With the aid of the single-virus tracking technique and the quantum dot-labeling strategy, the internalization of the pseudorabies virus (PrV) has been visualized in real time. The results demonstrate that macropinocytosis can be considered as a major pathway for PrV entering HeLa cells, which facilitates the development of therapeutics for virus-triggered diseases.
引用
收藏
页码：11184 / 11187
页数：4
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