Cobalt(III)-Catalyzed Fast and Solvent-Free C-H Allylation of Indoles Using Mechanochemistry

被引：68

作者：

Jiang, Xinpeng ^{[1
]}

Chen, Jinkang ^{[1
]}

Zhu, Weijie ^{[1
]}

Cheng, Kang ^{[1
]}

Liu, Yong ^{[1
]}

Su, Wei-Ke ^{[2
]}

Yu, Chuanming ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 19期

基金：

中国国家自然科学基金;

关键词：

BOND ACTIVATION; ALLYLIC ALCOHOLS; COBALT CATALYSIS; ROOM-TEMPERATURE; BALL MILL; FUNCTIONALIZATION; AMIDATION; ARENES; ALKYNES; ISOQUINOLINES;

D O I：

10.1021/acs.joc.7b01695

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mechanochemical conditions have been applied to a highly efficient cobalt(III)-catalyzed C-H bond activation for the first time. In a subsequent step to the olefin insertion and beta-oxygen elimination, N-pyrimidinylindoles were allylated with vinylethylene carbonate's in the absence of organic solvent under high-speed ball-milling condition. As the reaction afforded the desired products in up to 98% yields within a short time, this method constitutes an environmentally friendly and powerful alternative to the common solution-based approaches.

引用

页码：10665 / 10672

页数：8

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