The influence of environment and origin on brain resident macrophages and implications for therapy

被引：82

作者：

Bennett, Mariko L. ^{[1
]}

Bennett, F. Chris ^{[2
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

NATURE NEUROSCIENCE | 2020年 / 23卷 / 02期

关键词：

HEMATOPOIETIC-CELL TRANSPLANTATION; X-LINKED ADRENOLEUKODYSTROPHY; MICROGLIA-LIKE CELLS; YOLK-SAC; PRIMITIVE MACROPHAGES; ALZHEIMERS-DISEASE; AXONAL SPHEROIDS; PROGENITOR-CELL; GENE-THERAPY; FETAL LIVER;

D O I：

10.1038/s41593-019-0545-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia are the tissue-resident macrophages of the brain and spinal cord. They are critical players in the development, normal function, and decline of the CNS. Unlike traditional monocyte-derived macrophages, microglia originate from primitive hematopoiesis in the embryonic yolk sac and self-renew throughout life. Microglia also have a unique genetic signature among tissue resident macrophages. Recent studies identify the contributions of both brain environment and developmental history to the transcriptomic identity of microglia. Here we review this emerging literature and discuss the potential implications of origin on microglial function, with particular focus on existing and future therapies using bone-marrow- or stem-cell-derived cells for the treatment of neurological diseases. Framed around the potential use of microglia as new cellular therapies for brain disease, Bennett and Bennett review new discoveries about the effects of developmental origin and environmental signals on brain macrophage identity and function.

引用

页码：157 / 166

页数：10

共 130 条

[1] iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases [J].

Abud, Edsel M. ;

Ramirez, Ricardo N. ;

Martinez, Eric S. ;

Healy, Luke M. ;

Nguyen, Cecilia H. H. ;

Newman, Sean A. ;

Yeromin, Andriy V. ;

Scarfone, Vanessa M. ;

Marsh, Samuel E. ;

Fimbres, Cristhian ;

Caraway, Chad A. ;

Fote, Gianna M. ;

Madany, Abdullah M. ;

Agrawal, Anshu ;

Kayed, Rakez ;

Gylys, Karen H. ;

Cahalan, Michael D. ;

Cummings, Brian J. ;

Antel, Jack P. ;

Mortazavi, Ali ;

Carson, Monica J. ;

Poon, Wayne W. ;

Blurton-Jones, Mathew .

NEURON, 2017, 94 (02) :278-+

[2] The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease [J].

Aflaki, Elma ;

Westbroek, Wendy ;

Sidransky, Ellen .

NEURON, 2017, 93 (04) :737-746

[3] Local self-renewal can sustain CNS microglia maintenance and function throughout adult life [J].

Ajami, Bahareh ;

Bennett, Jami L. ;

Krieger, Charles ;

Tetzlaff, Wolfram ;

Rossi, Fabio M. V. .

NATURE NEUROSCIENCE, 2007, 10 (12) :1538-1543

[4] Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool [J].

Ajami, Bahareh ;

Bennett, Jami L. ;

Krieger, Charles ;

McNagny, Kelly M. ;

Rossi, Fabio M. V. .

NATURE NEUROSCIENCE, 2011, 14 (09) :1142-U263

[5] Long-Term Functional Outcomes after Hematopoietic Stem Cell Transplant for Early Infantile Krabbe Disease [J].

Allewelt, Heather ;

Taskindoust, Mahsa ;

Troy, Jesse ;

Page, Kristin ;

Wood, Susan ;

Parikh, Suhag ;

Prasad, Vinod K. ;

Kurtzberg, Joanne .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2018, 24 (11) :2233-2238

[6] Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain [J].

Alliot, F ;

Godin, I ;

Pessac, B .

DEVELOPMENTAL BRAIN RESEARCH, 1999, 117 (02) :145-152

[7]

[Anonymous], GENEREVIEWS

[8] Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction [J].

Arnold, Thomas D. ;

Lizama, Carlos O. ;

Cautivo, Kelly M. ;

Santander, Nicolas ;

Lin, Lucia ;

Qiu, Haiyan ;

Huang, Eric J. ;

Liu, Chang ;

Mukouyama, Yoh-Suke ;

Reichardt, Louis F. ;

Zoyein, Ann C. ;

Sheppard, Dean .

JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (04) :900-915

[9] Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain [J].

Askew, Katharine ;

Li, Kaizhen ;

Olmos-Alonso, Adrian ;

Garcia-Moreno, Fernando ;

Liang, Yajie ;

Richardson, Philippa ;

Tipton, Tom ;

Chapman, Mark A. ;

Riecken, Kristoffer ;

Beccari, Sol ;

Sierra, Amanda ;

Molnar, Zoltan ;

Cragg, Mark S. ;

Garaschuk, Olga ;

Perry, V. Hugh ;

Gomez-Nicola, Diego .

CELL REPORTS, 2017, 18 (02) :391-405

[10] Epigenetic regulation of brain region-specific microglia clearance activity [J].

Ayata, Pinar ;

Badimon, Ana ;

Strasburger, Hayley J. ;

Duff, Mary Kaye ;

Montgomery, Sarah E. ;

Loh, Yong-Hwee E. ;

Ebert, Anja ;

Pimenova, Anna A. ;

Ramirez, Brianna R. ;

Chan, Andrew T. ;

Sullivan, Josefa M. ;

Purushothaman, Immanuel ;

Scarpa, Joseph R. ;

Goate, Alison M. ;

Busslinger, Meinrad ;

Shen, Li ;

Losic, Bojan ;

Schaefer, Anne .

NATURE NEUROSCIENCE, 2018, 21 (08) :1049-+

← 1 2 3 4 5 6 7 8 9 10 →