Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity

被引：40

作者：

Antonio Suarez-Cuenca, Juan ^{[1
,2
,3
]}

De la Pena-Sosa, Gustavo ^{[1
]}

De la Vega-Moreno, Karen ^{[1
]}

Zaineff Banderas-Lares, Diana ^{[1
]}

Salamanca-Garcia, Moises ^{[4
]}

Enrique Martinez-Hernandez, Jose ^{[1
]}

Vera-Gomez, Eduardo ^{[1
]}

Hernandez-Patricio, Alejandro ^{[1
]}

Ramiro Zamora-Aleman, Carlos ^{[1
]}

Alexandra Dominguez-Perez, Gabriela ^{[1
]}

Sua Ruiz-Hernandez, Atzin ^{[1
]}

Ariel Gutierrez-Buendia, Juan ^{[1
]}

Melchor-Lopez, Alberto ^{[3
,5
]}

Ortiz-Fernandez, Moises ^{[6
]}

Montoya-Ramirez, Jesus ^{[6
]}

Felipe Gaytan-Fuentes, Omar ^{[6
]}

Toriz-Ortiz, Angelica ^{[7
]}

Osorio-Valero, Mario ^{[7
]}

Orozco-Vazquez, Julita ^{[7
]}

Lizeth Alcaraz-Estrada, Sofia ^{[8
]}

Eunice Rodriguez-Arellano, Martha ^{[9
]}

Maldonado-Arriaga, Brenda ^{[1
]}

Perez-Cabeza de Vaca, Rebeca ^{[10
]}

Escamilla-Tilch, Monica ^{[10
]}

Antonio Pineda-Juarez, Juan ^{[10
]}

Antonio Tellez-Gonzalez, Mario ^{[10
]}

Garcia, Silvia ^{[1
]}

Mondragon-Teran, Paul ^{[10
]}

机构：

[1] ISSSTE, Ctr Med Nacl 20 Noviembre, Div Res, Lab Expt Metab & Clin Res,Dept Clin Res, 502 San Lorenzo, Mexico City 03100, DF, Mexico

[2] IMSS, Internal Med Dept, HGZ 58 Manuel Avila Camacho, Mexico City 03340, DF, Mexico

[3] Hosp Gen Xoco SS CDMX, Mexico City 03340, DF, Mexico

[4] ISSSTE, Ctr Med Nacl 20 Noviembre, Pathol Dept, Mexico City 03104, DF, Mexico

[5] IMSS, Internal Med Dept, HGZ 8 Gilberto Flores Izquierdo, Mexico City 03340, DF, Mexico

[6] ISSSTE, Ctr Med Nacl 20 Noviembre, Bariatr Surg Dept, Mexico City 03100, DF, Mexico

[7] ISSSTE, Ctr Med Nacl 20 Noviembre, Diagnost Imaging Dept, Mexico City 03100, DF, Mexico

[8] ISSSTE, Ctr Med Nacl 20 Noviembre, Lab Med Genom, Mexico City 03100, DF, Mexico

[9] ISSSTE, Hosp Reg Lic Adolfo Lopez Mateos, Lab Med Genom, Mexico City, DF, Mexico

[10] ISSSTE, Ctr Med Nacl 20 Noviembre, Coordinat Res & Tissue Engn & Regenerat Med Res G, Mexico City 03100, DF, Mexico

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

INSULIN-RESISTANCE; CELL-SIZE; BODY-FAT; EXPRESSION; DEPOT;

D O I：

10.1038/s41598-021-81289-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Morphological characteristics and source of adipose tissue as well as adipokines may increase cardiometabolic risk. This study aimed to explore whether adipose tissue characteristics may impact metabolic and atherogenic risks. Subcutaneous Adipose Tissue (SAT), Visceral Adipose Tissue (VAT) and peripheral blood were obtained from obese patients submitted to bariatric surgery. Adipose tissue (morphometry), plasma adiponectin, TNF-alpha, resistin (multiplexing) and biochemical chemistry were analyzed; as well as endothelial dysfunction (Flow Mediated Dilation, FMD) and atherogenesis (Carotid Intima Media Thickness, CIMT). Subgroups divided by adipocyte size and source were compared; as well as correlation and multivariate analysis. Sixty patients 36.6% males, aged 44 years-old, BMI 46.7 kg/m(2) were included. SAT's adipocytes showed a lower range of size expandability than VAT's adipocytes. Independent from their source, larger adipocytes were associated with higher glucose, lower adiponectin and higher CIMT. Particularly, larger adipocytes from SAT were associated with higher blood pressure, lower insulin and HDL-cholesterol; and showed positive correlation with glucose, Hb(A1c), systolic/diastolic values, and negatively correlated with insulin and adiponectin. VAT's larger adipocytes particularly associated with lower resistin and lower FMD values. Gender and Diabetes Mellitus significantly impacted the relation of adipocyte size/source with the metabolic and atherogenic risk. Multivariable analysis suggested hypertension-resistin-Hb(A1c) interactions associated with SAT's larger adipocytes; whereas potential insulin-adiponectin associations were observed for VAT's larger adipocytes. Adipocyte morphology and source are differentially related with cardiometabolic and atherogenic risk in population with obesity, which are potentially affected by gender and Diabetes Mellitus.

引用

页数：11

共 53 条

[11] Adipocyte Size Threshold Matters: Link with Risk of Type 2 Diabetes and Improved Insulin Resistance After Gastric Bypass [J].