Emerging role of miRNAs in renal fibrosis

被引：51

作者：

Fan, Youling ^{[1
,2
]}

Chen, Hongtao ^{[3
]}

Huang, Zhenxing ^{[4
]}

Zheng, Hong ^{[5
]}

Zhou, Jun ^{[6
]}

机构：

[1] First Peoples Hosp, Dept Anesthesiol, Kashgar, Xinjiang Provin, Peoples R China

[2] Panyu Cent Hosp, Dept Anesthesiol, Guangzhou, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Dept Anesthesiol, Guangzhou, Guangdong, Peoples R China

[4] First Peoples Hosp Foshan, Dept Anesthesiol, 81 Lingnan Ave North, Foshan 528000, Guangdong, Peoples R China

[5] Xinjiang Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Urumqi, Xinjiang Provin, Peoples R China

[6] Southern Med Univ, Affiliated Hosp 3, Dept Anesthesiol, Guangzhou, Guangdong, Peoples R China

来源：

RNA BIOLOGY | 2020年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Renal fibrosis; miRNA; TRANSFORMING-GROWTH-FACTOR; TO-MESENCHYMAL TRANSITION; TUBULAR EPITHELIAL-CELLS; ACUTE KIDNEY INJURY; DIABETIC-NEPHROPATHY; TGF-BETA; PROMOTES FIBROGENESIS; THERAPEUTIC TARGETS; LUPUS NEPHRITIS; GENE-EXPRESSION;

D O I：

10.1080/15476286.2019.1667215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As one type of the most common endogenous short noncoding RNAs (ncRNAs), microRNAs (miRNAs) act as posttranscriptional regulators of gene expression and have great potential biological functions in the physiological and pathological processes of various diseases. The role of miRNAs in renal fibrosis has also attracted great attention in the previous 20 years, and new therapeutic strategies targeting miRNAs appear to be promising. Some researchers have previously reviewed the roles of miRNA in renal fibrosis disease, but numerous studies have emerged over the recent 5 years. It is necessary to update and summarize research progress in miRNAs in renal fibrosis. Thus, in this review, we summarize progress in miRNA-mediated renal fibrosis over the last 5 years and evaluate the biological functions of some miRNAs in different stages of renal fibrosis. Furthermore, we also expound the recent clinical applications of these miRNAs to provide new insights into the treatment of renal fibrosis disease.

引用

页码：1 / 12

页数：12

共 129 条

[1] Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy [J].

Alvarez, M. Lucrecia ;

Khosroheidari, Mahdieh ;

Eddy, Elena ;

Kiefer, Jeff .

PLOS ONE, 2013, 8 (10)

[2] MicroRNA-146a in Human and Experimental Ischemic AKI: CXCL8-Dependent Mechanism of Action [J].

Amrouche, Lucile ;

Desbuissons, Geoffroy ;

Rabant, Marion ;

Sauvaget, Virginia ;

Nguyen, Clement ;

Benon, Aurelien ;

Barre, Pauline ;

Rabate, Clementine ;

Lebreton, Xavier ;

Gallazzini, Morgan ;

Legendre, Christophe ;

Terzi, Fabiola ;

Anglicheau, Dany .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (02) :479-493

[3] Erythropoietin Inhibits Hypoxia-Induced Epithelial-To-Mesenchymal Transition via Upregulation of miR-200b in HK-2 Cells [J].

Bai, Jiuxu ;

Xiao, Xiao ;

Zhang, Xiaoling ;

Cui, Hanmin ;

Hao, Junfeng ;

Han, Jingming ;

Cao, Ning .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 42 (01) :269-280

[4] MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy [J].

Bai, Xiaoyan ;

Geng, Jian ;

Zhou, Zhanmei ;

Tian, Jianwei ;

Li, Xiao .

SCIENTIFIC REPORTS, 2016, 6

[5] Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy [J].

Bao, Hao ;

Hu, Shuai ;

Zhang, Changming ;

Shi, Shaolin ;

Qin, Weisong ;

Zeng, Caihong ;

Zen, Ke ;

Liu, Zhihong .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 444 (04) :455-460

[6] Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion [J].

Bera, Amit ;

Das, Falguni ;

Ghosh-Choudhury, Nandini ;

Mariappan, Meenalakshmi M. ;

Kasinath, Balakuntalam S. ;

Choudhury, Goutam Ghosh .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2017, 313 (04) :C430-C447

[7] Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy [J].

Bhatt, Kirti ;

Lanting, Linda L. ;

Jia, Ye ;

Yadav, Sailee ;

Reddy, Marpadga A. ;

Magilnick, Nathaniel ;

Boldin, Mark ;

Natarajan, Rama .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (08) :2277-2288

[8] Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation [J].

Bijkerk, Roel ;

de Bruin, Ruben G. ;

van Solingen, Coen ;

van Gils, Janine M. ;

Duijs, Jacques M. G. J. ;

van der Veer, Eric P. ;

Rabelink, Ton J. ;

Humphreys, Benjamin D. ;

van Zonneveld, Anton Jan .

KIDNEY INTERNATIONAL, 2016, 89 (06) :1268-1280

[9] Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGFβR1 [J].

Brennan, Eoin P. ;

Nolan, Karen A. ;

Boergeson, Emma ;

Gough, Oisin S. ;

McEvoy, Caitriona M. ;

Docherty, Neil G. ;

Higgins, Debra F. ;

Murphy, Madeline ;

Sadlier, Denise M. ;

Ali-Shah, Syed Tasadaque ;

Guiry, Patrick J. ;

Savage, David A. ;

Maxwell, Alexander P. ;

Martin, Finian ;

Godson, Catherine .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 24 (04) :627-637

[10] Serum microRNAs levels in primary focal segmental glomerulosclerosis [J].

Cai, Xiaoyi ;

Xia, Zhengkun ;

Zhang, Chunni ;

Luo, Yang ;

Gao, Yuanfu ;

Fan, Zhongmin ;

Liu, Mengyuan ;

Zhang, Ying .

PEDIATRIC NEPHROLOGY, 2013, 28 (09) :1797-1801

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